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ICR 12000


ICR 12000

The ICR 12000 is designed for ultra-high throughput ion channel screening of compound libraries, incorporating multi-channel sampling and enhanced automation features. Based upon the versatility, precision, and sensitivity of Aurora Biomed’s atomic absorption spectroscopy (AAS) instruments, the ICR 12000 is suitable for both ligand-gated and voltage-gated ion channels using cell-based flux assays. With the robustness of Aurora Biomed’s ICR technology, the reader offers high sensitivity for both electrogenic and non-electrogenic channels and transporters. The incredible 60,000 sample per day throughput of the ICR 12000 enables ion channel researchers to access compound QT liability early in the drug discovery process.
Download Brochure





Specifications

  • Medium Throughput: Up to 5000 wells/day
  • Single Channel: Measures 1 sample at a time
  • Minimum sample volume: 50 µl
  • Accommodation: 96/384-well microplates
  • Footprint: H.67 cm X W.55 cm X D.37 cm
  • Fuel Source: Acetylene / Compressed Air
  • Options: Plate Stacker / Bar Code Reader
  • Sensitivity: 0.05 ppm detection limit
  • Precision: < 5% CV


Features & Benefits

  • Programmable and automated solution for up to 60,000 wells/day
  • Automatic dilution, calibration and cleaning
  • Integrated plate stacker & bar code reader
  • Sample dilution not required
  • High sensitivity
  • On-line dilution
  • Eliminates quenching effects associated with fluorescence
  • Removes need to work with hazardous radioisotopes
  • Avoids work restrictions posed by Rb’s short half-life
  • Ideal for hERG channel assays
  • Can assess both electrogenic and non-electrogenic transporters


Independently Validated

Researchers from Roche performed high-throughput screening campaigns for modulators of a cation-chloride co-transporter using the ICR 12000.

Download their poster from the 2016 Ion Channel Summit to see how Roche developed a high throughput rubidium (Rb+) uptake assay for measuring NKCC1 function and subsequently screened 1.2 million compounds using Aurora’s ICR 12000.

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