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Scientific Program and Schedule 2014

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Speaking Program

 

Wednesday, November 5th, 2014

  • 8:00 – 8:30 Registration
  • 8:30 – 9:00 Welcome & Opening Remarks – Aurora Biomed Inc.

New Horizons of Life Sciences 1

  • 9:00 – 9:30 Keynote/Chair: Ling Chen – Executive Director, Professor, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences – Ion channels as drug targets for antiviral therapeutics
  • 9:30 – 9:55 Joseph Tam – CEO/CSO, Diagcor Bioscience Ltd. – Molecular diagnosis for everyone in the next decade: wishful thinking or realistic aspiration?
  • 9:55 – 10:20 Zhiyuan Li – Investigator, Ghuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences – Vitamin E isomer δ-tocopherol enhances the efficiency of neural stem cell differentiation via L-type calcium channel
  • 10:20 – 10:50 Coffee Break

Ion Channels as Disease Targets 1

  • 11:40 – 12:05 Haowei Shen – Principal Investigator, National Institute on Drug Dependence, Peking University – The role of NMDA receptor in relapse to drug seeking
  • 12:05 – 1:05 Lunch

New Horizons of Life Sciences 2

  • 2:00 – 2:25 Chuanxin Yang – Associate Director, Biology, WuXi AppTec – Electrophysiological determination of ion channel development in human embryonic stem cell-induced cardiomyocytes
  • 2:25 – 2:55 Coffee Break

Ion Channels as Disease Targets 2

  • 2:55 – 3:20 Keynote/Chair: Xiaoliang Wang – Professor, Institute of Materia Medica, Chinese Academy of Medical Sciences – The pathophysiological and new drug target study of TREK-1, a two-pore domain potassium ion channel subtype
  • 4:30 – 5:30 Chinese Language Workshops
  • Haoyu Zeng – Principal Scientist, Merck Sharp & Dohme – In vitro cardiac safety pharmacology
  • Xin Jiang – Manager, Application Science Molecular Devices, Inc. – Total solution for ion channel research from Molecular Devices

 

Thursday, November 6th, 2014

  • 8:30 AM – 8:35 AM – Opening Remarks – Aurora Biomed Inc.

Ion Channel and Transporter Screening Technologies

  • 9:05 – 9:30 Xin Jiang – Manager, Application Science, Molecular Devices, Inc. – Characterization of sodium channel neurotoxins on the IonWorks Barracuda® Plus automated patch clamp system
  • 9:30 – 9:55 Paul Li – Professor, Department of Chemistry and Department of Molecular Biology and Chemistry, Simon Fraser University – Ginsenoside Rg3 inhibits multidrug resistance transporters revealed by the same single cell analysis on a microfluidic chip
  • 9:55 – 10:25 Coffee Break
  • 10:25 – 10:50 Keynote/Chair: Kewei Wang – Qingdao University School of Pharmacy, Peking University School of Pharmaceutical Sciences – Identification and functional validation of novel TRPV channel modulators from natural products
  • 11:15 – 11:40 Shouming Du – Product Manager, HAMAMATSU –Use of electric field stimulations (EFS) to pace the beating of human iPSC-derived cardiomyocytes in 96-well plate
  • 11:40 – 12:05 Rodolfo Haedo – Vice President, North America, Nanion – A revolutionary modular approach: Bridging the gap between primary and secondary screening with the Syncropatch Patch Engine
  • 12:05 – 1:05 Lunch

Alcohol, Tobacco and Ion Channels

  • 1:05 – 1:35  Keynote/Chair:  David Lovinger – Deputy Director, Division of Clinical and Biomedical Science and Chief, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health – Presynaptic calcium channels in dopaminergic and glutmatergic afferents to the striatum
  • 1:35 – 2:00 Jie Wu – Director of Neurophysiology Laboratory and Professor, Department of Neurology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center – α6*-nAChRs in the VTA are a critical target for alcohol reward and dependence
  • 2:00 – 2:25 Paul Slesinger – Professor, Department of Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine – Insights into the structural mechanism underlying alcohol activation of GIRK channels: a new therapeutic target
  • 2:25 – 2:55 Coffee Break
  • Chair: Li Zhang – Medical Officer, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse Alcoholism, National Institutes of Health
  • 2:55 – 3:20 Robert Peoples – Professor, Department of Biomedical Sciences, Marquette University – Sites of alcohol action at the intersubunit interfaces of the NMDA receptor
  • 4:30 – 5:30 Chinese Language Workshops TBA
  • 6:00 Pearl River Boat Cruise

 

Friday, November 7th, 2014

  • 8:30 AM – 8:35 AM – Opening Remarks – Aurora Biomed Inc.

Ion Channels as Pain Targets

  • 8:35 – 9:05 Keynote/Chair: Guang-Yin Xu – Principal Investigator, Key Laboratory for Translational Pain Medicine, Institute of Neuroscience, Soochow University – Purinergic P2X receptor channels and chronic visceral pain
  • 9:05 – 9:30 Jeffrey Herz – President and CEO, Algomedix, Inc. – Discovery of a novel class of allosteric antagonists targeting TRPA1 receptor-channels with peripheral acting analgesic activity
  • 9:30 – 9:55 Haibo Yu – Principal Investigator, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Neuroscience, School of Medicine, Johns Hopkins University – Application of automated electrophysiology to identify state-dependent and isoform-specific sodium channel blockers
  • 9:55 – 10:25 Coffee Break
  • 10:50 – 11:15 Xian-Guo Liu – Pain Research Center, Zhongshan School of Medicine, Sun Yat-Sen University – Differential regulation of sodium channels and ClC-3 chloride channels in DRG neurons by TNF-α contributes to neuropathic pain
  • 11:15 – 11:40 Lishuang Cao – Pfizer – Evaluating TRESK channel as a pain target using a selective opener
  • 11:40 – 12:05 Jun-Li Cao – Xuzhou Medical College – Neuro-adaptations of mesolimbic reward circuit in depression and chronic pain
  • 12:05 – 1:05 Lunch

Cardiac Safety and Pharmacology

  • 1:05 – 1:35 Keynote/Chair: Chris Mathes – Chief Commercial Officer, ChanTest – Addicted to Safety: Assays for better cigarettes and medicines
  • 1:35 – 2:00 Long Chen – Director, Department of Pharmacology, National Standard Laboratory of Pharmacology for Chinese Materia Medica, Institute of Chinese Medicine of Taizhou China Medical City – Proarrhythmia risk underlying the clinical use of processed Radix Aconiti Lateralis Preparata
  • 2:00 – 2:25 Yingji Li – Executive Vice President, ICE Bioscience – Electrophysiological characterization of human stem cell derived cardiomyocytes
  • 2:25 – 2:55 Coffee Break
  • 2:55 – 3:20 Yue Ma – Professor, Institute of Biophysics, Chinese Academy of Sciences – A drug safety assessment model based on hPES-CMs
  • 3:20 – 3:45 Heming Wei – Senior Research Scientist, National Heart Research Institute Singapore – Assessment of the therapeutic potential of a novel Iks activator for Type 1 Long QT syndrome using patient-specific induced pluripotent stem cell-derived cardiomyocytes
  • 3:45 – 4:10 Huaiyu Yang – Professor, Drug Design and Discovery Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences – Dynamic interactions of small molecules with Kv channels
  • 4:10 – 4:30 Dong Liang – President & CEO, Aurora Biomed Inc. – Closing Remarks

 

Poster Program

 

  • Weiping Wang – State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College – Discovery of anti-ischemia drug based on two-pore-domain potassium channel TREK-1
  • Erica Li – Center for Women’s Reproductive Sciences Research, Department of Obstetrics and Gynecology, Washington University in St. Louis – Ryanodine Receptor modulates BK channel induced nuclear translocation of NF-kB in Human myometrium
  • Zhenfeng Liu – Professor, National Heart Centre Singapore – Electrophysiological assessment of cardiac safety of alcohol using human induced pluripotent stem cell-derived cardiomyocytes as model
  • Pingzheng Zhou – Associate Professor, School of Pharmaceutical Sciences, Southern Medical University in Guangzhou – PIP2 regulation on the pharmacological selectivity and gating of KCNQ channel
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