Ion Channel Technology
ICR 8000 Ion Channel Reader
Invaluable for ion channel screening, the ICR 8000 - ion channel technology, detects ion channel activity using atomic absorption spectroscopy and flux assays. Current applications include the evaluation of the hERG potassium channel more quickly, more precisely and more accurately than other medium to high throughput ion channel screening systems. Interactions with the hERG channel can lead to prolonged QT syndrome. Thus, regulatory agencies require the assessment of QT liability.
The ICR 8000 displays broad utility; it can be applied to assess both voltage-gated (hERG, BK/SK, Kv1.1, 1.4, 1.5, KCNQ, 2P,etc.) and ligand-gated (KATP, nAChR, etc.) ion channels. This allows researchers to accelerate drug development efforts in the treatment and prevention of diseases associated with ion channels.
Benefits |
- programmable and automated
- Automatic dilution, calibration and cleaning
- Adaptable to existing robotic automation
- Sample dilution not required
- High sensitivity
- On-line dilution
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Features |
- Medium Throughput: Up to 5000 wells/day
- Single Channel: Measures 1 sample at a time
- Minimum sample volume: 50 µl
- Accommodation: 96/384-well microplates
- Footprint: H.67 cm X W.55 cm X D.37 cm
- Fuel Source: Acetylene / Compressed Air
- Options: Plate Stacker / Bar Code Reader
- Sensitivity: 0.05 ppm detection limit
- Precision: < 5% CV
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Eliminates |
- Quenching effects associated with fluorescence
- Health hazards associated with radioisotopes
- Radioisotope disposal
- Work restrictions posed by Rb's short half-life
- Ideal for hERG channel assays
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Strategies for the real-time detection of Ca2+ channel events of single cells: recent advances and new possibilities
ICR 12000 Ion Channel Reader
 The ICR 12000 was designed for ultra high throughput ion channel screening of compound libraries against ion channel targets. Based on the robustness of Aurora Biomed's ICR technology, the reader offers high sensitivity generating accurate drug rank order matching electrophysiology data. This new member of the ICR ion channel screening series provides the throughput to access compound QT liability early in the drug discovery process.
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Technology |
The technology is based upon the versatility, precision, and sensitivity of atomic absorption spectroscopy (AAS) and Aurora Biomed's patented microsampling process. Ion Channel Technology is suitable for both ligand-gated and voltage-gated ion channels using cell-based flux assays. |
Features |
- High Throughput: Up to 60,000 wells/day
- Multi-Channel: Measures 12 samples at a time
- Minimum sample volume: 20 µl
- Accommodation: 96/384-well microplates
- Footprint: H.135 cm X W.134cm X D.97cm
- Fuel Source: Natural Gas / Compressed Air
- Includes: Plate Stacker / Bar Code Reader
- Sensitivity: 0.05 ppm detection limit
- Precision: < 5% CV
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Applications |
ICR technology is suitable for many types of ion channels broad applications include:
- Shaker (Kv1.1, Kv1.4 and Kv1.5)
- hERG
- KCNQ4
- B/SKCa
- KCNB/TASK-3
- Kir2.1
- nAChR
- KATP (P2X family)
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Download the brochure on Aurora's Ion Channel Readers:
