9th Annual Ion Channel Retreat

Vancouver BC, Canada - June 27 – 29, 2011

Read the 2010 Ion Channel Retreat Review

Speaking Program (subject to change)

June 27th, 2011

• 7:45 AM - 8:50 AM Registration in Foyer & Breakfast in Georgia Ballroom

• 8:50 AM - 8:55 AM Welcome & Opening Remarks - TBA, Aurora Biomed Inc

Ion Channels as Disease Targets

• 8:55 AM Chairperson’s Remarks

• 9:00 AM - 9:30 AM - Robert Petroski - Project Manager, Dart Neuroscience - In Search of Memory Drugs

• 9:30 AM - 10:00 AM - Robert Kass - Vice Dean for Research, Columbia University - Heritable Arrhythmias: Broad Lessons from Rare Diseases

• 10:00 AM - 10:30 AM - Clint Young - Senior Research Scientist, Xenon Pharmaceuticals Inc - Block Of hDMT11 By XEN601, A Small Molecule Useful For Treating Iron Overload Disorders

• 10:30 AM - 11:00 AM Coffee Break in Georgia Ballroom

• 11:00 AM - 11:30 AM - Catherine Howsham - Research Investigator II, Novartis Pharmaceuticals UK Limited - ENaC blockers for the treatment of Cystic Fibrosis

• 11:30 AM - 12:00 PM - Kenneth Stauderman - Vice President Research, CalciMedica - CRAC Channels as Targets for Autoimmune/Inflammatory Disorders

Ion Channels as Pain Targets

• 12:00 PM - Chairperson’s Remarks

• 12:05 PM - 12:35 PM - Li Zhang - Medical Officer, National Institute on Alcohol Abuse and Alcoholism - Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia

• 12:35 PM - 1:35 PM - Lunch in Plaza C Ballroom

• 1:35 PM - 2:05 PM - Greg Kaczorowski - Founder, Kanalis Consulting LLC - Targeting Cav2.2 Channels to Treat Chronic Pain

• 2:05 PM - 2:35 PM - Torben Neelands - Senior Scientist III, Abbott Neuroscience - A-1165442: A TRPV1 antagonist with differential in vitro pharmacology and lacks in vivo hyperthermia

TRP Channels as Pain & Disease Targets

• 2:35 PM - Chairperson’s Remarks

• 2:40 PM - 3:10 PM - Jeffrey M. Herz - President and CEO, Algomedix, Inc. - Targeting TRPA1 Channels for Chronic Pain: Understanding a Structural Diversity of Ligands

• 3:10 PM - 3:40 PM - Coffee Break in Georgia Ballroom

• 3:40 PM - 4:10 PM - Jose L. Mercado - Senior Fellow, Washington University - Role of PIP2 on Ca2+-dependent desensitization of TRPV2

• 4:10 PM - 4:40 PM - Jack M Stewart - CSO, Soricimed Biopharma Inc - Advances in TRPV6-based diagnostics for cancer

• 4:40 PM - 5:10 PM - Stuart E. Dryer - Professor and Chair, University of Houston - NMDA Receptors in podocytes – A possible target for glomerulodegenerative diseases

June 28th, 2011

• 7:45 AM - 8:20 AM - Breakfast in Georgia Ballroom

• 8:20 AM - 8:25 AM - Opening Remarks - TBA, Aurora Biomed Inc

Ion Channel Screening Technologies

• 8:25 AM Chairperson’s Remarks

• 8:30 AM - 9:00 AM - Ali Yehia - Applications Scientist, Sophion - QPatch analysis software: Avoiding the bottleneck

• 9:00 AM - 9:30 AM - Stephen Smith - Technical Director, Fluxion - Automated patch clamp redefined

• 9:30 AM - 10:00 AM - Adam Hendricson - Lead Evaluation, Bristol-Myers Squibb (speaking on behalf of Nanion) - Bridging the gaps in ion channel hit-to-lead with SyncroPatch 96: ultra-high throughput auto-EP

• 10:00 AM - 10:30 AM - Coffee Break in Georgia Ballroom

• 10:30 AM - 11:00 AM - Andrew Baxter- Senior Research Scientist, Evotec - P2X receptors a pain worth chasing

• 11:00 AM - 11:30 AM - Andreas Nolting - Senior Research Scientist, AstraZeneca R&D Södertälje (speaking on behalf of Cellectricon) - Talk

• 11:30 AM - 12:00 PM - Fernanda Laezza - Assistant Professor, University of Texas Medical Branch - A novel bioluminescence-based assay for functional evaluation of the Nav channelosome

• 12:00 PM - 1:00 PM - Lunch in Plaza C Ballroom

• 1:00 PM - 1:30 PM - Sikander Gill - Director of Application Development, Aurora Biomed - An Overview of Tracer ion Flux Assay Technology and Its Automation on VERSA Workstation

• 1:30 PM - 2:00 PM - Yuri Kuryshev - Senior Project Director, ChanTest Corporation (speaking on behalf of Molecular Devices Inc.)Development of Novel Ion Channel Drug Discovery and Safety Assays using IonWorks Barracuda and Quattro Automated Electrophysiology Systems

• 2:00 PM - 2:30 PM - Ralf Kettenhofen - Senior Scientist, Axiogenesis - Pure Cardiomyocytes Derived from Pluripotent Stem Cells: One Cell Type for Multiple Cardiac Targets in High Throughput Assay Formats

• 2:30 PM - 3:00 PM - Coffee Break in Georgia Ballroom

• 3:00 PM - 3:30 PM - Stephen Hess - Senior R&D Manager, Cell Based Assays, EMD Millipore - Developing Cardiac Safety and Drug Discovery Target Efficacy Assays for KCNQ (Kv7) Ion Channels

• 3:30 PM - 4:00 PM - Steven Petrou - Associate Director & Head, Ion Channels and Disease Laboratory, Florey Neuroscience Institutes, The University of Melbourne - Is dynamic clamp a viable tool for ion channel drug discovery?

• 4:00 PM - 4:30 PM - Jacob Schmidt - Associate Professor of Pharmacology, UCLA Department of Bioengineering - Artificial lipid bilayer platforms for cell-free ion channel screening

• 5:15 PM - Meet in Hyatt lobby for boat cruise

• 5:30 PM - 6:00 PM - Shuttle to Granville Island & Boarding of M.V. Burrard Queen

• 6:00 PM - 9:00 PM - Boat cruise sponsored by EMD Millipore.

June 29th, 2011

• 7:45 AM - 8:20 AM - Breakfast in Georgia Ballroom

• 8:20 AM - Opening Remarks - TBA, Aurora Biomed Inc

Cardiac Function and Pharmacology

• 8:25 AM - Chairperson’s Remarks

• 8:30 AM - 9:00 AM - David Madge - VP, Research, Xention Ltd. - Discovery of atrial-selective ion channel blockers for the treatment of atrial fibrillation

• 9:00 AM - 9:30 AM - Cathy Smith-Maxwell - Senior Research Scientist, Gilead - Cardiac Sodium Channel Blockade for Treating Ischemic Heart Disease

• 9:30 AM - 10:00 AM - Guy Salama - Professor, Cardiovascular Institute, University of Pittsburgh - Properties of L-type Ca2+ channels are determinants of intracellular Ca2+ load and cardiac arrhythmias

• 10:00 AM - 10:30 AM - Weinian Shou - Professor, Riley Heart Research Center, Indiana University School of Medicine - FKBP12 is a Critical Regulator of the Heart Rhythm and the Cardiac Voltage-Gated Sodium Current in Mice

• 10:30 AM - 11:00 AM - Coffee Break in Georgia Ballroom

Cardiac Safety and Toxicology

• 11:05 AM - Chairperson’s Remarks

• 11:05 AM - 11:35 AM - Arthur "Buzz" Brown - Executive Chairman & CSO, ChanTest Corporation - Cardiac Ion Channel Screening for Drug Discovery and Safety

• 11:35 AM - 12:05 PM - Sabina Kupershmidt - Res. Assoc. Prof. Anesthesiology and Pharmacology, Vanderbilt University School of Medicine - Identification of a Novel Compound that Reduces Sensitivity to hERG Inhibitors and Prevents hERG-related, Drug-induced Arrhythmias in Isolated Rabbit Hearts

• 12:05 PM - 12:35 PM - Blake Anson - Product Manager, Cellular Dynamics International - Multi-platform evaluation of human induced pluripotent stem cell derived cardiomyocyte ion channel function and pharmacology

• 12:35 PM - 1:35 PM - Lunch in Plaza C Ballroom

Structure & Function of Ion Channels

• 1:35 PM - Chairperson’s Remarks

• 1:40 PM - 2:10 PM - Geoffrey T. Swanson - Associate Professor, Northwestern University Feinberg School of Medicine - Modulation of AMPA and kainate receptor function by galectins

• 2:10 PM - 2:40 PM - Heike Wulff - Associate Professor, University of California, Davis - Inner Pore Residues Mediate the Binding of the Kv1.3 Blocker PAP-1 and the Negative KCa2 Channel Gating Modulator NS8593

• 2:40 PM - 3:10 PM - David D. Busath - Professor, Brigham Young University - Structure-Activity Relationships Of Known Influenza A M2 Inhibitors

• 3:10 PM - 3:25 PM - Closing Remarks - TBA - Aurora Biomed Inc

PRELIMINARY LIST OF POSTERS

Monday, June 27th, 2011

• Kelly Gatfield - Senior Scientist, Glaxosmithkline - Assay development and triage strategy for the screening of ENaC blockers

• Georgi V. Petkov - Associate Professor of Pharmacology, University of South Carolina - KCa1.1 channel of the human detrusor smooth muscle: a promising pharmacological target for urinary bladder dysfunction

• Pengcheng Han - Postdoctoral fellow, University of Calgary - Tumor Necrosis Factor alpha enhances the glutamatergic currents in spinal motoneurons—implication for spinal cord injury

• Stefan Tasler - Senior Scientist, Chemistry, 4SC AG - 4SC's Potassium Channel Kv1.3 Inhibitors: Efficacy in Animal Models

• Stephane Renauld - MSc / PhD candidate, University of Sherbooke - Stimulation of ENaC activity by rosiglitazone is PPARγ-dependent and correlates with SGK1 expression increase

Tuesday, June 28th

• Antonio Guia - Vice President, Aviva Biosciences - Functional and pharmacological properties of human neuronal and cardiac Nav1.7

• Eric Stava - Research Assistant, University of Wisconsin-Madison - Inertial Flow in an Open, High-Speed Microfluidic Planar Patch Clamp System

• James Costantin - Application Scientist, Molecular Devices Inc - IonWorks Barracuda Automated Electrophysiology System Measures Ligand- or Voltage-gated Ion Channels Simultaneously in 384 Wells

• Per-Eric Lund - Associate principle scientist, Neuroscience, Astrazeneca - Studies of neuroblastoma cell lines using Ionworks

• Volker Nimmrich - Head of in vitro electrophysiology, Abbott Neuroscience Research - Modulation of recombinant P/Q-type calcium currents by A globulomer - an automated analysis using the Patchliner

Wednesday, June 29th

• Jessica Law - PhD Candidate, The Hong Kong University of Science and Technology - Using the microelectrode array to study the involvements of KATP channel subtypes of rat atrial slices under normoxic and hypoxic conditions

• Lynn Kimlicka - PhD Candidate, University of British Columbia - Crystallographic investigation of disease-associated mutations in Ryanodine Receptors

• Momoh Yakubu - Senior Scientist & Head, Vascular Biology Unit, Texas Southern University - Regulation of cerebral and renal microcirculation by acid sensing ion channels: a possible role for PPARalpha

• Rocío Del Pilar Rincón López - MSc Candidate, National University of Colombia - Study of Ca2+ channel blockade effect on pulmonary vasculature and hypoxic pulmonary arterial hypertension in broiler in a model in vivo and in vitro

• Zerrin Kuras - Postdoctoral Fellow, University of Cincinnati - Ca2+-activated K+ channels (KCa3.1) control activated T cell migration