10th Annual Ion Channel Retreat

Vancouver BC, Canada - June 25 - 27, 2012

Read the 2011 Ion Channel Retreat Review

Speaking Program (subject to change)

Monday, June 25th, 2012

• 7:45 AM - 8:50 AM Registration in Foyer & Breakfast

• 8:50 AM - 8:55 AM Welcome & Opening Remarks - TBA, Aurora Biomed Inc

Ion Channels as Disease Targets

• 8:55 AM Chairperson’s Remarks

• 9:00 AM - 9:30 AM - Jerod Denton - Assistant Professor of Anesthesiology and Pharmacology, Vanderbilt University School of Medicine - Of mosquitoes and men: renal potassium channels as novel disease targets

• 9:30 AM - 10:00 AM - Fumihito Ono - Chief, Section on Model Synaptic Systems, National Institutes of Health - A model of fetal akinesia rescued by acetylcholine receptor subunit gene expression

• 10:00 AM - 10:30 AM - Shawn P. Iadonato - EVP & Chief Scientific Officer, KINETA Inc. - Development of Kv1.3 channel blocker ShK-186 for the treatment of autoimmune disease: nonclinical perspectives

• 10:30 AM - 11:00 AM Coffee Break in Georgia Ballroom

• 11:00 AM - 11:30 AM - Xin-Ming Shen - Assistant Professor of Neurology, Mayo Clinic (Rochester) - Key role of myasthenic syndrome mutant residue in loop-C of AChR α-subunit

• 11:30 AM - 12:00 PM - Stefan Bittner - Postdoctoral Fellow, University Hospital Muenster - Two-pore domain potassium channels represent novel targets for autoimmune disorders

• 12:00 PM - 12:30 PM - Lunch in Plaza C Ballroom

TRP Channels as Pain & Disease Targets

• 1:00 PM - Chairperson’s Remarks

• 1:05 PM - 1:35 PM - Jeffrey M. Herz - President and CEO, Algomedix, Inc. - Allosteric Regulation of TRPA1 Channels: Implications for Drug Design

• 1:35 PM - 2:05 PM - Stuart E. Dryer - John and Rebecca Moores Distinguished Professor, University of Houston - Interactions between podocin and TRPC6 channels

• 2:05 PM - 2:35 PM - Mike Iadarola - Principal Investigator, National Institutes of Health - Multiple pathways for pain control using TRPV1 ion channel agonists and positive allosteric modulators

• 2:35 PM - 3:00 PM Coffee Break in Georgia Ballroom

Ion Channels as Pain Targets

• 3:00 PM - Chairperson’s Remarks

• 3:05 PM - 3:35 PM - Li Zhang - Medical Officer, National Institutes of Health - Cannabinoids suppress inflammatory and neuropathic pain by targeting a3 glycine receptors

Ion Channel Structure & Function

• 3:35 PM - Chairperson’s Remarks

• 3:40 PM - 4:10 PM - Harley Kurata - Assistant Professor, University of British Columbia - How do ATP-sensitive potassium channels translate cellular metabolism into electrical signals?

Tuesday, June 26th, 2012

• 8:00 AM - 8:20 AM - Breakfast in Georgia Ballroom

• 8:20 AM - 8:25 AM - Opening Remarks - TBA, Aurora Biomed Inc

Ion Channel Screening Technologies

• 8:25 AM Chairperson’s Remarks

• 8:30 AM - 9:00 AM - Jeffrey Zidichouski - Senior Research Officer, National Research Council Canada - Ex Vivo Focal Ischemic Stroke Model For Drug Discovery

• 9:00 AM - 9:30 AM - Chris Benjamin - Team Lead Ion Channel Service Operations, EMD Millipore - Millipore - GABAA α1-6 Ion Channel Profiling Assays for Drug Discovery Across Multiple Platforms

• 9:30 AM - 10:00 AM - Elaine Gay - Research Pharmacologist, RTI International - Fluxion - target="_blank">Development and Optimization of an Automated Electrophysiological Assay for the Neuronal a4b2 Nicotonic Receptor using the IonFlux 16

• 10:00 AM - 10:30 AM - Coffee Break in Georgia Ballroom

• 10:30 AM - 11:00 AM - Dave Rock - Sr. Project Leader, Ion Channel Screening, Essen BioScience - High-throughput, functional pharmacology of voltage and ligand gated ion channels

• 11:00 AM - 11:30 AM - Rodolfo Haedo - General Manager, Nanion Technologies - Patch clamp screening of a7 nAChRs and the temperature dependence of allosteric modulation

• 11:30 AM - 12:30 PM - Lunch in Plaza C Ballroom

• 12:30 PM - 1:00 PM - Glenn Kirsch - Sr. Director, ChanTest Corp - Development of GABAA Receptor Assays for Drug Discovery and Safety Profiling in IonWorks® Barracuda™ Automated Patch Clamp

• 1:00 PM - 1:30 PM - Olaf Scheel - Chief Scientific Officer, Cytocentrics Bioscience GmbH - Automated patch clamp data confirms structure based in silico predicition of compound cardiotoxicity

• 1:30 PM - 2:00 PM - Hervør Lykke Olsen - Scientific Service Manager, Sophion - Current Clamp Recordings on QPatch: Action potentials and pharmacological effects measured in HL-1 immortalized atrial cardiomyocytes

• 2:00 PM - 2:30 PM - Coffee Break in Georgia Ballroom

• 2:30 PM - 3:00 PM - Peter Miu - Field Applications Scientist, Molecular Devices - Evaluation of Solution Exchange Rates and Multiple Compound Additions on the IonWorks Barracuda System

• 3:00 PM - 3:30 PM - Stephan Steigele - Scientific Account Manager, Genedata AG - High-volume data analysis workflows for microfluidics-based automated patch clamp experiments increase both the sample throughput and detail level of their biological characterization

• 4:45 PM - Meet in Hyatt lobby for boat cruise

• 5:30 PM - 6:00 PM - Shuttle to Granville Island & Boarding of M.V. Burrard Queen

• 6:00 PM - 9:00 PM - Boat cruise sponsored by EMD Millipore.

Wednesday, June 27th, 2012

• 8:30 AM - 8:50 AM - Coffee in Georgia Ballroom

• 8:50 AM - Opening Remarks - TBA, Aurora Biomed Inc

Cardiac Safety and Toxicology

• 8:55 AM - Chairperson’s Remarks

• 9:00 AM - 9:30 AM - Buzz Brown - Founder and Chief Scientific Officer, Chantest - A New Method of Predicting Drug-Induced Cardiac Risk

• 9:30 AM - 10:00 AM - Andrew Wojtovich - Postdoctoral Fellow, University of Rochester Medical Center - Mitochondrial BK channels and cardioprotection

• 10:00 AM - 10:30 AM - Takashi Yoshinaga - Senior Principal Scientist, Eisai Co.Ltd. (Japan) - Chronic probucol treatment decreases the slow component of the delayed-rectifier potassium current in CHO cells

• 10:30 AM - 11:00 AM - Coffee Break in Georgia Ballroom

• 11:00 AM - 11:30 AM - Ruth L. Martin- Sr. Scientist II, Abbott (GPRD) - Small molecule combination hERG screening - A case study

• 11:30 AM - 12:00 PM - Gul Erdemli - Head of Ion Channel Group, Novartis Institutes for BioMedical Research, Inc - Integrated risk assessment for Nav1.5-mediated cardiac safety liabilities

• 12:00 PM - 12:30 PM - Coffee Break in Georgia Ballroom

Cardiac Function and Pharmacology

• 12:30 PM - Chairperson’s Remarks

• 12:35 PM - 1:05 PM - Tina Garyantes - CEO, MaxSAR Biopharma - Miniaturization of Cardiac Beating Assays

• 1:05 PM - 1:35 PM - Balwant Tuana - Prof, Pharmacology, Dept. Cellular and Molecular Medicine, University of Ottawa. - The CaMKII anchoring protein aKAP targets the sarcoplasmic reticulum and regulates calcium transporters: A novel therapeutic target for calcium signaling.

• 1:35 PM - 1:50 PM - Closing Remarks - TBA - Aurora Biomed Inc

POSTER PRESENTATIONS

Monday, June 25th, 2012

• Ali Ahmadi - Postdoctoral Research Fellow, University of British Columbia - Micro-Engineering Three-Dimensional In vitro Tissue Constructs

• Avid Khamenehfar - Ph.D. Candidate,Simon Fraser University - Enhancement of Drug Accumulation in AML-193 cells by Blocking ABCB1 and ABCC1 Transporters Studied in a Microfluidic Chip

• Chris Chambers - Scientist, Neusentis (Pfizer Ltd) - Compound evaluation of hNav1.7 and hNav1.5 assays using IonWorks Quattro and PatchXpress 7000A

• Karim Nagi - Ph.D. Candidate, Ste-Justine Hospital Research Center & University of Montreal - K1R3.1/3.2 Channels and Delta Opioid Receptors form constitutive signalling complexes that are modulated by β-arrestin2

• Luciano Moffatt - Investigator, CONICET University of Buenos Aires - Achieving solution exchange in the tens of microseconds range for patch clamp experiments

Tuesday, June 26th, 2012

• Ali Ahmadi - Postdoctoral Research Fellow, University of British Columbia - Micro-Engineering Three-Dimensional In vitro Tissue Constructs

• Ali Yehia - Director of Global IonFlux Sales and Services, Fluxion Biosciences - Assay Development for Ligand Gated Ion Channel Pharmacology

• Chris Chambers - Scientist, Neusentis (Pfizer Ltd) - Compound evaluation of hNav1.7 and hNav1.5 assays using IonWorksTM Quattro

• Debebe Gebremedhin - Associate Professor of Physiology, Medical College of Wisconsin - Functional role of Ca2+-activated K+ channels in neurovascular coupling mediated regulation of cerebral blood flow

• Luciano Moffatt - Investigator, CONICET University of Buenos Aires - Achieving solution exchange in the tens of microseconds range for patch clamp experiments

Wednesday, June 27th, 2012

• Ali Yehia - Director of Global IonFlux Sales and Services, Fluxion Biosciences - Assay Development for Ligand Gated Ion Channel Pharmacology

• Avid Khamenehfar - Ph.D. Candidate,Simon Fraser University - Enhancement of Drug Accumulation in AML-193 cells by Blocking ABCB1 and ABCC1 Transporters Studied in a Microfluidic Chip

• Debebe Gebremedhin - Associate Professor of Physiology, Medical College of Wisconsin - Functional role of Ca2+-activated K+ channels in neurovascular coupling mediated regulation of cerebral blood flow

• Graciela Pineyro - Chercheure Agrégée, Université de Montréal - Bioluminescence Resonance Energy transfer (Bret) Biosensors

• Sabina Kupershmidt - Research Associate Professor, Vanderbilt University, - Novel Approaches to Therapy for hERG-Related, Drug-Induced Arrhythmias