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Speaking Program 2013

ionChannelRetreatLogo2013

Speaking Program

Monday, June 24th, 2013

  • 7:30 AM – 8:30 AM Registration in Pavilion Foyer & Breakfast in Pavilion D Meal Room
  • 8:30 AM – 8:35 AM Welcome & Opening Remarks – TBA, Aurora Biomed Inc
  • 8:35 AM – 9:00 AM – KEYNOTE: Gregory Kaczorowski – President and CEO, Kanalis Consulting, L.L.C. – The Role of Kv2 Channels in Pancreatic Hormone Secretion

Ion Channels as Disease Targets

  • 9:00 AM Chairperson’s Remarks
  • 9:05 AM – 9:25 AM – Kenneth Byron – Professor, Molecular Pharmacology and Therapeutics, LUMC – Kv7 channels in smooth muscle as therapeutic targets for vascular and airway diseases
  • 9:25 AM – 9:45 AM – Wilson Edwards – Principal Scientist, Janssen Pharmaceuticals, Johnson & Johnson PRD – Engineered Scorpion Venom Peptide Fusion Proteins as Potent, Selective, Long Half-Life Kv1.3 Inhibitors
  • 9:45 AM – 10:05 AM – Steven Petrou – Deputy Director, Division of Epilepsy, The Florey Institute, University of Melbourne – High content, high throughput analysis of sodium channel variants in epilepsy
  • 10:05 AM – 10:35 AM Coffee Break in Pavilion Foyer
  • 10:35 AM – 10:55 AM – Heike Wulff – Associate Professor, Pharmacology, University of California, Davis – Small- and Intermediate-Conductance KCa Channels as Targets for Cardiovascular and Neurological Diseases
  • 10:55 AM – 11:15 AM – Marzia Martina – Research Officer, Leader of Physiology Section, Department of Translational Bioscience, Human Health Therapeutics Portfolio, National Research Council of Canada – Memantine differentially modulates NMDA receptors in pyramidal neurons and interneurons
  • 11:15 AM – 11:35 AM – Petra Ehling – Post-Doctoral Researcher, Neurology Clinic and Institute of Neuropathophysiology, University Hospital Muenster – Ca2+-dependent large conductance K+ currents in thalamocortical relay neurons of epileptic WAG/Rij and non-epileptic ACI rats
  • 11:35 AM – 11:55 AM – David M. Rock – Director, US Discovery Services, Essen BioScienceExecuting on NaV Drug Discovery with the IonWorks Barracuda® Automated Electrophysiology Platform
  • 11:55 AM – 12:15 PM – Li Zhang – Medical Research Officer, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health – Presynaptic glycine receptors as a therapeutic target in familial startle disease
  • 12:15 PM – 1:15 PM – Lunch in Pavilion D Meal Room

TRP Channels as Pain & Disease Targets

  • 1:15 PM – Chairperson’s Remarks
  • 1:20 PM – 1:40 PM – Jeffrey Herz – President and CEO, Algomedix, Inc. – A Novel Class of Ligands Targeting the TRPA1 Receptor-Channel: Discovery of a Switch in Agonist-Antagonist Function
  • 1:40 PM – 2:00 PM – Jose Mercado – Senior Fellow, University of Washington – TRPing on arterial myocytes: local control of Ca2+ influx via TRPV4 channel
  • 2:00 PM – 2:20 PM – Stuart Dryer – John and Rebecca Moores Distinguished Professor, University of Houston – A role for NOX2 in chemical modes of activation of TRPC6 channels in podocytes
  • 2:20 PM – 2:50 PM Coffee Break in Pavilion Foyer

Ion Channels as Pain Targets

  • 2:50 PM – Chairperson’s Remarks
  • 2:55 PM – 3:15 PM – Kuldip Khakh & Clint Young – Research Scientist & Senior Scientist, Head of Electrophysiology, Xenon Pharmaceuticals – Block of NaV1.7 for the Treatment of Pain
  • 3:15 PM – 3:35 PM – Paolo Cesare – Senior Scientist, Natural and Medical Sciences Institute at the University of Tübingen – High-density microelectrode arrays as a new tool to investigate modulation of sensory neuron excitability in vitro
  • 3:35 PM – 3:55 PM – Matt Fuller – Senior Scientist, Electrophysiology, Pfizer – Neusentis – Pharmacology and Biophysics of Selective Na Channel Blockers

Structure & Function of Ion Channels, Part I

  • 3:55 PM – Chairperson’s Remarks
  • 4:00 PM – 4:20 PM – Dale Laird – Professor and Canada Research Chair in Gap Junctions and Disease, Schulich School of Medicine & Dentistry, University of Western Ontario – Trafficking, assembly and function of pannexin channels and their role in cell differentiation
  • 4:20 PM – 4:40 PM – Armagan Koçer – Assistant Professor, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen – Hydrophobic gating of a mechanosensitive ion channel and its applications on biosensors and in vivo triggered liposomal drug delivery

Tuesday, June 25th, 2013

  • 7:30 AM – 8:30 AM – Breakfast in Pavilion D Meal Room
  • 8:30 AM – 8:35 AM – Opening Remarks – TBA, Aurora Biomed Inc
  • 8:35 AM – 9:00 AM – KEYNOTE: Chris Mathes – Chief Commercial Officer, ChanTest Corporation – The recent history of automated patch clamp: an insider’s perspective

Ion Channel Screening Technologies

  • 9:00 AM Chairperson’s Remarks
  • 9:05 AM – 9:25 AM – Fernanda Laezza – Assistant Professor, Pharmacology and Toxicology, University of Texas Medical Branch – Towards integrated screening platforms to interrogate ion channel macromolecular complexes
  • 9:25 AM – 9:45 AM – James Costantin – Product Marketing Manager, Automated Electrophysiology, Molecular Devices, LLC – Investigating Use-Dependent Inhibition of Ion Channels on the IonWorks Barracuda System
  • 9:45 AM – 10:05 AM – Matt Bridgland-Taylor – Associate Principal Scientist, Discovery Sciences, AstraZenecaExploitation of Barracuda Automated Electrophysiology Platform to Improve Assessment of Cardiac Liability
  • 10:05 AM – 10:35 AM – Coffee Break in Pavilion Foyer
  • 10:35 AM – 10:55 AM – Sikander Gill – Director, Application Development, Aurora Biomed, Inc. – High-Throughput Screening of Ion Co-Transporters using Tracer Flux and Ion Channel Reader Technology
  • 10:55 AM – 11:15 AM – Joerg Oestreich – Senior Applications Scientist, Nanion Technologies Inc. – Minimized cell usage for stem cell-derived and primary cells on the Nanion Patchliner, an automated patch clamp system.
  • 11:15 AM – 11:25 AM – Richard Kondo – North American Sales Manager, Sophion Bioscience, Inc. – Sponsored Technical Talk: Qube – Merging Automated Patch Clamp with High Throughput Screening
  • 11:25 AM – 11:45 AM – Chris Chambers – Scientist, Neusentis (Pfizer Ltd) – Optimisation and Validation of an Automated Electrophysiological Assay for TRESK using Qpatch
  • 11:45 AM – 12:05 PM – David Gurley – Senior Research Scientist, Electrophysiology, Jubilant Discovery Services – Development of calcium flux and electrophysiological NMDA receptor assays
  • 12:05 AM – 1:05 PM – Lunch in Pavilion D Meal Room
  • 1:10 PM Chairperson’s Remarks
  • 1:10 PM – 1:30 PM – Timm Danker – Biologist, Electrophysiology, Natural and Medical Sciences Institute at the University of TübingenPatchserver: Automation of classical patch clamp featuring multi channel recordings, optical cell selection and ultra fast compound application
  • 1:30 PM – 1:50 PM – Emir Duzic – Senior Director, Discovery Services, ChanTest Corporation – Automated patch clamping for screening and profiling in drug discovery and risk assessment
  • 1:50 PM – 2:10 PM – Robert Petroski – Associate Manager, Dart Neuroscience – Optical and electrophysiological assays for screening GABAA receptors
  • 2:10 PM – 2:40 PM – Coffee Break in Pavilion Foyer
  • 2:40 PM – 3:00 PM – Evan Miller – Post-doctoral Fellow, Department of Pharmacology, University of California, San Diego – Optically monitoring transmembrane potential in excitable cells using photo-induced electron transfer through a molecular wire
  • 3:00 PM – 3:20 PM – Stephen Brough – Investigator, GlaxoSmithKline Inc.The IonWorks Barracuda Automated Population Patch Clamp System: Opportunities and Challenges in Implementing New Technologies in Electrophysiological Compound Profiling
  • 3:20 PM – 3:40 PM – Blake Anson – Product Manager, Cellular Dynamics International, Inc. – Human cells at the bench: Utilizing IPSC-technology to bring electrically active human cells into basic research and drug discovery efforts
  • 3:40 PM – 4:00 PM – Silke Schwengberg – Scientific Counsel, Axiogenesis AG – Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells as a Predictive Tool for Drug Profiling and Safety Pharmacology
  • 5:00 PM – 5:30 PM- Meet in Sheraton lobby for boat cruise
  • 5:30 PM – 6:00 PM- Shuttles to 1676 Duranleau St & Boarding of M.V. Burrard Queen
  • 6:00 PM – 9:00 PM – Boat cruise sponsored by ChanTest Corporation

Wednesday, June 26th, 2013

  • 7:30 AM – 8:30 AM – Breakfast in the Port Rooms Corridor
  • 8:30 AM – Opening Remarks – TBA, Aurora Biomed Inc
  • 8:35 AM – 9:00 AM – KEYNOTE: Bernard Fermini – Associate Research Fellow, Pfizer – A new approach to study cardiac function using a classic method. Review of a case study

Structure & Function of Ion Channels, Part II

  • 9:00 AM – Chairperson’s Remarks
  • 9:05 AM – 9:25 AM – Paul G. DeCaen – Postdoctoral Fellow of Pediatrics and Cardiology, Harvard Medical School, Children’s Hospital Boston, Howard Hughes Medical Institute – Structural insights into sodium channel activation, ion selectivity and pharmacology
  • 9:25 AM – 9:45 AM – David Busath – Professor, Physiology and Developmental Biology, Brigham Young University – SPersistent in vitro inhibition of Influenza A by amantadine analogs
  • 9:45 AM – 10:15 AM – Coffee Break in the Port Rooms Corridor
  • 10:15 AM – 10:35 AM – Anna Moroni – Professor, Biosciences, University of Milan – Discovery and characterization of a distinct cyclic nucleotide binding pocket in HCN channels
  • 10:35 AM – 10:55 AM – Filip Van Petegem – Associate Professor, Biochemistry and Molecular Biology, University of British Columbia – Crystallographic insights into the Ryanodine Receptor: an analysis of disease mutations
  • 10:55 AM – 11:15 AM – Daniel Minor – Professor, University of California, San Francisco – Pore-only prokaryotic sodium channel structure: Insights into gating, selectivity, and relationship to eukaryotic channels
  • 11:15 AM – 12:15 PM – Lunch in the Port Rooms Corridor

Cardiac Function and Pharmacology

  • 12:15 PM – Chairperson’s Remarks
  • 12:20 PM – 12:40 PM – Anna Bukiya – Assistant Professor, Pharmacology, College of Medicine, University of Tennessee Health Science Center – PUse of automated patch-clamp technology for identification of multiple steroid-sensing sites in the vascular smooth muscle BK channel
  • 12:40 PM – 1:00 PM – Balwant Tuana – Professor, Pharmacology, University of Ottawa – PSLMAP, a Novel Regulator of Cardiac Excitation-Contraction Coupling
  • 1:00 PM – 1:30 PM – Coffee Break in the Port Rooms Corridor

Cardiac Safety and Toxicology

  • 1:30 PM – Chairperson’s Remarks
  • 1:35 PM – 1:55 PM – Tomohiko Taniguchi – Senior Principal Researcher, Eisai Co, Ltd – Probucol and the cholesterol synthesis inhibitors simvastatin and triparanol regulate IKs channel function differently
  • 1:55 PM – 2:15 PM – Weinian Shou – Professor, Pharmacology and Toxicology, Indiana University School of Medicine – The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity
  • 2:15 PM – 2:35 PM – Ruth Martin – Senior Scientist III, AbbVie – Enhancing Automated Screening with Measured Concentrations
  • 2:35 PM – 2:50 PM – Closing Remarks – TBA – Aurora Biomed Inc
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