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Speaking Program & Schedule 2015

ionChannelRetreat2015Logo

Program at a Glance*

*Tentative and Subject to Change

Speaking Program

Tuesday Morning, July 7th, 2015

  • 7:30 Registration
  • 8:45-9:00 Welcome & Opening Remarks – Aurora Biomed Inc.

 

Cardiac Safety and Pharmacology

 

  • 9:00-9:25 Keynote: Arthur Brown – Chan Test / Charles River – Comprehensive In Vitro Proarrhythmia Assay (CiPA) in action

 

  • 9:30-9:55 Shouming Du – Hamamatsu – Electric Field Stimulation (EFS) of human iPS cardiomyocytes and primary neurons

 

Structure, Function and Engineering of Ion Channels

  • 10:00-10:25 Chair: Frank Horrigan – Baylor School of Medicine – Mechanisms of BK channel modulation

 

  • 10:30-10:55 Coffee Break & Posters

 

  • 11:00-11:25 Saverio Gentile – Loyola University Chicago – Targeting voltage-gated K+ channels in cancer reveal new biochemical pathways and therapeutic opportunities

 

  • 11:30-11:55 Eric Accili – University of British Columbia – Energetics of cyclic AMP binding to HCN channel C terminus reveal negative cooperativity

 

  • 12:00-12:25 Geerten Vuister – University of Leicester – Differential calmodulin-TRPV interactions in response to Ca2+ mediate channel regulation

 

  • 12:25-13:15 Lunch

 

  • 13:15-13:55 Posters and Networking

 

Tuesday Afternoon, July 7th, 2015

Transporters and Ion Pumps

 

  • 14:00-14:25 Christopher Triggle – Weill Cornell Medical College at Qatar – Metformin; an old drug but with new targets that affect endothelial function: eNOS, transporters, cancer and aging

 

  • 14:30-14:55 Chair: Larry Fliegel – University of Alberta – Molecular characterization of the Na+/H+ exchanger In human disease

 

  • 15:00 – 15:25  Coffee Break & Posters

 

  • 15:30-15:55 Nathan Zahler – XRPro – Label-free, High Throughput Ion Channel & Transporter Assays: case studies for TRPA1 & nonelectrogenic transporters

 

  • 16:00-16:25 Paul Li – Simon Fraser University –Integrated microfluidic device for drug accumulation measurement on a single MDR transporter-expressing prostate cancer cell isolated among blood cells

 

  • 16:25-16:55 Sikander Gill – Aurora Biomed – Tracer Ion Flux Technology for Co-transporter Drug Discovery

 

Wednesday Morning, July 8th, 2015

  • 8:00 Registration
  • 8:50-9:00 Welcome & Opening Remarks – Aurora Biomed Inc.

 

Ion Channel Screening Technologies

  • 9:00-9:25 Chair: Richard Kondo – Sophion- Qube – bringing direct Ion Channel recordings to HTS

 

  • 9:30-9:55 David Dalrymple – SB Drug Discovery – TRP channels-challenges and strategies for drug discovery

 

  • 10:00-10:25 Chris Chambers – Pfizer – High Throughput Screening of NaV1.7 Assay using Qube Automated Electrophysiological System

 

  • 10:30-10:55 Coffee Break & Posters

 

  • 11:00-11:25 Joe McGivern – Amgen Inc. – Evaluation of SyncroPatch 384PE in an HTS setting

 

  • 11:30-11:55 George Okeyo – Nanion- Complementary HTS Technologies towards a more rigorous safety screening paradigm

 

  • 12:00-12:25 Glenn Kirsch – Chan Test / Charles River – Development of screening tools to identify Nicotinic Receptor Subtype-Selective Compounds

 

  • 12:30-13:25 Lunch

 

Wednesday Afternoon, July 8th, 2015

Ion Channels as Disease Targets

  • 13:30-13:55 Chair: Shawn Iadonato – Kineta Inc. – Dalazatide, first-in-class Kv1.3 blocker, an immunomodulator’s journey from the sea to the clinic

 

  • 14:00-14:25 Annarosa Arcangeli – University of Florence – Ion channels: novel biomarkers and therapeutic targets in cancer

 

  • 14:30-14:55 Coffee Break & Posters

 

  • 15:00-15:25 Hailin Zhang – Hebei Medical University – Targeted modulation of Kv7/KCNQ channel in dopaminergic neurons of ventral tegmental area affect the neuronal excitability and behavior of depression model


  • 15:30-15:55 Hannah Gaunt – University Leeds – (-)- Englerin A as a novel potent activator of TRPC4 and TRPC5 channels

 

  • 16:00-16:25 David Hackos – Genentech – Identification and characterization of novel NMDA receptor positive allosteric modulators (PAMs)

 

  • 16:30-17:00 Posters and Networking

 

18:00 Boat Cruise Boarding

 

Thursday Morning, July 9th, 2015

  • 8:00 Registration
  • 8:15-8:25 Welcome & Opening Remarks – Aurora Biomed Inc.

 

Alcohol, Tobacco and Ion Channels

  • 8:30-8:55 Chair: Andrew Holmes – US National Institute of Health – Alcohol effects on prefrontal NMDA receptor circuits mediating fear

 

  • 9:00-9:25 Javier Camacho – CINVESTAV, I.P.N. Mexico – Cigarette smoke and estradiol exposure regulate mouse AQP5, TRPC3 and TRPV1 ion channel expression in the lung, liver and kidneys

 

  • 9:30-9:55 Zhang Li – NIAAA/NIH – GlyRs contribute to ethanol-induced behaviors in brain

 

  • 10:00-10:25 Coffee Break & Posters

 

Structure, Function and Engineering of Ion Channels

  • 10:30-10:55 Chair: Richard Olsen – UCLA – Biochemical identification of an Ethanol-sensitive benzodiazepine binding site on delta subunit-containing gaba-A receptors

 

  • 11:00-11:25 Yu Zhou – Washington University in St. Louis, School of Medicine – A new insight into an old toxin: allosteric inhibition of the BK-type channel by paxilline receptors

 

  • 11:30-11:55 Rajnish Ranjan – Blue Brain Project EPFL Switzerland – The Channelome and Channelpedia (Automated biophysical characterization of complete Kv-Ion channel family)

 

  • 12:00-12:55 Lunch

 

Thursday Afternoon, July 9th, 2015

Ion Channels as Pain Targets

  • 13:00-13:25 Chair: Ru-Rong Ji – Duke University – Modulation of TRP channels by resolvins in mouse and human

 

  • 13:30-13:55 Nikita Gamper – University of Leeds – Role of ANO1 (TMEM16A) channels in inflammatory pain

 

  • 14:00-14:25 Yan Xu – University of Pittsburg – Engineered Ion Channels as Receptor Therapeutics for the Treatment of Inflammatory Pain

 

  • 14:30-14:55 Coffee Break & Posters

 

  • 15:00-15:25 Van Lu – US National Institute of Health – Utilizing an Scn10a-EGFP reporter mouse to study changes in Nav1.8 expression in peripheral sensory neurons and abnormal Nav1.8 expression in the central nervous system

 

  • 15:30-15:55 Xinzhong Dong – Johns Hopkins University School of Medicine – Tmem100 is a regulator of TRPA1-TRPV1 complex and contributes to persistent pain

 

  • Dong Liang – President & CEO, Aurora Biomed Inc. – Closing Remarks

 

Poster Program

 

  • Jose Mercado – Kineta Inc – Preclinical development of novel conesnail peptide-based analgesics that selectivelyinhibit the α9α10 nicotinic acetylcholine receptor

 

  • Kayla Norton – Kineta Inc – Kv1.3 channel blocker Dalazatide: a potential novel therapeutic for ANCA vasculitis and lupus nephritis

 

  • Xiaona Du – Hebei Medical University – Controlling somatic resting membrane potential of nociceptive neurons as target of pain

 

  • Ari Alexandrou – Neusentis (Pfizer) – Investigating the role of Nav1.7 using native human neuronal cultures

 

  • Nathan Zahler – XRPro – Label-free, High Throughput Ion Channel & Transporter Assays: Case Studies for TRPA1 & Nonelectrogenic Transporters

 

  • Martin Wong – Maxcyte – Simple and Effective Generation of Cell-based Assays for the Efficient Screening of Drug Candidates in Biologically Relevant Cells Using Scalable Transient Transfection

 

  • Irene Gregan – Merck – New Method of Batch Processing PatchXpress Data to Support Nav 1.7 Program

 

  • Beiyan Zou – Molecular Devices – A comparison of cell-based thallium-sensitive fluorescence assay with automated electrophysiology: In vitro potency evaluation of hERG inhibitors

 

  • Marc Rogers – Metrion Biosciences – Optimising a difficult Nav1.8 cell line assay for automated patch clamp screening

 

  • Kaylee Magee – Simon Fraser University – HCN channel C-terminal region speeds activation rates independently of autoinhibition

 

  • Ghérici Hassaine – Theranyx – Binder generation against membrane proteins

 

  • Shawna Stanwood – University British Columbia – The role of the P2X7 receptor in T lymphocytes

 

  • Khaled Barakat – University of Alberta – A comprehensive atomistic model for the human Nav1.5 Sodium Ion channel: Toward understanding the molecular origin behind cardiotoxicity
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