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Speaking Program & Schedule 2017

Speaking Program and Schedule

7:30 AM – 8:30 AM – Registration

8:30 AM – 8: 40AM – Welcome & Opening Remarks: Sophia Liang, Aurora Biomed Inc.

 

Keynote Presentation

8:40 AM – 9:20AM – Brad Nelson

Director and Distinguished Scientist, Deeley Research Centre, BC Cancer Agency – “Customizing cancer immunotherapies to match the intrinsic tumor microenvironment”

 

PM Session: Immunotherapies and Cancer Treatment

9:20 AM – 9:25 AM – Chair: David Rabuka

Global Head of R&D, Chemical Biology, Catalent

 

9:25 AM – 9:45 AM – David Rabuka

Global Head of R&D, Chemical Biology, Catalent – “Developing Site-Specifically Modified Antibody Drug Conjugates (ADCs) Using a Chemoenzymatic Approach

 

9:45 AM – 10:05 AM – Ester Falconer

Senior Scientist, Abcellera – “Deep screening of natural immune repertoires to generate candidate therapeutic antibodies against difficult targets

 

10:05 AM – 10:25 AM – William Jia

Associate Professor, Brain Research Centre, University of British Columbia – “Oncolytic virotherapy: Ignite the fire of anti-tumor immunity in tumor microenvironment

 

10:25 AM – 10:55 AM – Coffee Break & Posters

 

10:55 AM – 11:00 AM – Chair: Brad Nelson

Director and Distinguished Scientist, Deeley Research Centre, BC Cancer Agency

 

11:00 AM – 11:20 AM – Eric Holland

Senior VP and Director, Fred Hutchinson Cancer Research Center – “Using Mouse Models to Develop Immunotherapy Strategies for Gliomas”

 

11:20 AM – 11:40 AM – Christopher Triggle

Professor, Department of Pharmacology, Weill Cornell Medicine, Qatar – “Metformin: Does it have a role as an anti-cancer drug? If so it is all about the transporters”

 

11:40 AM – 12:00 PM – Heinrich Brinkmeier

Institute of Pathophysiology University Medicine Greifswald – “The plant alkaloid harmaline blocks the human voltage-gated sodium channel Nav1.7 expressed in CHO cells: a study using automated patch clamp”

 

Novel Perspective of Ion Channels in Precision Medicine

 

12:00 PM – 12:30 PM – Dong Liang

CEO, Aurora Biomed Inc – “Label-free Technologies of Ion Channels and Transporters: Rubidium Efflux Assay”

 

12:30 PM – 1:30 PM – Lunch

 

1:30 PM – 1:35 PM – Chair: Charlie Cohen

VP Biology, Xenon Pharmaceuticals

 

1:35 PM – 1:55 PM – Annarosa Arcangeli

Professor in Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Italy – “A novel perspective in personalized medicine: exploiting ion channels for cancer patients’stratification”

 

1:55 PM – 2:20 PM – Charlie Cohen

VP Biology, Xenon Pharmaceuticals – “A Novel Pain and Target Engagement Assay for hNaV1.7: efficacy in inflammatory and neuropathic pain models correlates with block of NaV1.7”

 

2:20 PM – 2:40 PM – JP Johnson

Senior Director, Cellular and Molecular Biology, Xenon Pharmaceuticals – “Selective targeting of NaV1.6 in an EIEE13 mouse model of epilepsy”

 

2:40 PM – 3:00 PM – Isabelle Deschenes

Professor of Medicine,, Case Western Reserve University – “Identification of New Long QT Syndrome Type 2 Modifier Genes Using a Physiological Genomics Approach”

 

3:00 PM – 3:20 PM – Saverio Gentile

Assistant Professor, Loyola University Chicago – “A Channelopathy called Cancer: From the understanding of K+ channel-dependent signaling to the design of novel precision cancer medicine”

 

3:20 PM – 3:55 PM – Coffee Break & Posters

 

IC Session: Ion Channels as Pain Target

3:55 PM – 4:00 PM – Chair: Chris Mathes

CSO Icagen

 

4:00 PM – 4:20 PM – Neil Castle

VP Research, Icagen – “Targeting Nav 1.9 for Development of New Pain Therapies”

 

4:20 PM – 4:40 PM – Bryan Moyer

Principal Scientist, Amgen – “NaV1.7 Inhibitory Peptide Conjugated to Carrier Antibody Increases Half-Life and Promotes Tissue Biodistribution to Nerve Elements”

 

4:40 PM – 5:00 PM – Vincenzo Carnevale

Research Associate Professor, Temple University – “Sensing the environment: a glimpse into the microscopic mechanisms of pain”

 

5:00 PM – 5:20 PM – Yan Xu

Peter M. Winter Professor of Anesthesiology, Pharmacology & Chemical Biology, Physics & Astronomy, and Structural Biology, University of Pittsburgh – “NMR investigation of site-specific general anesthetic binding to the voltage-gated sodium channel NaChBac and the mechanisms of inhibition”

 

5:20 PM – 5:40 PM Jeffrey Herz

CEO, Algomedix – “Development of a Novel Class of TRPA1 Antagonists as Effective Analgesic Drugs in Multiple Models of Neuropathic Pain”

 

5:40 PM – 6:00 PM – Zhiyuan Li

Principal Investigator, Guangzhou Institutes Of Biomedicine And Health – “Overexpression of

thermo-TRPVs may promote the formation of the esophageal Squamous cell carcinoma”

8:00 AM – 8:30 AM – Registration

 

8:20 AM – 8: 25AM – Welcome & Opening Remarks: Aurora Biomed Inc

 

Keynote Presentation

8:25 AM – 9:05AM – Alfred George

Chair, Department of Pharmacology, Northwestern University – “Functional Annotation of Human Ion Channel Variants”

 

PM Session: Applications of NGS

9:05 AM – 9:10AM Chair: Alfred George

Department of Pharmacology, Northwestern University

 

9:10 AM – 9:30 AM – Ashleen Shadeo

Sector Manager, Health Genome BC – “Implementing Genomics in the Health Care System in Canada”

 

9:30 AM – 9:50 AM – Tao Chen

CEO, Paragon Genomics – “A Novel Amplicon-based NGS Target Enrichment Technology for Liquid Biopsies in Oncology”

 

9:50 AM – 10:10 AM – Amit Mahipal

Associate Professor, Mayo Clinic NGS – “How Molecular Testing has Changed Therapy Decisions in Colorectal Cancer”

 

10:10 AM – 10:30 AM – Gourab Bhattacharjee

Marketing Programs Manager, Oncology, Illumina – Immuno-Oncology Research Enabled Through Applied Advanced Genomic Techniques

 

10:30 AM – 10:50 AM – Coffee Break & Posters

 

Technologies and Technical Session

 

10:50 AM – 10:55 AM – Chair: Ali Yehia

VP IonFlux Product and Director of BioFlux Business Marketing, Fluxion

 

10:55 AM – 11:15 AM – Ali Yehia

VP IonFlux Product and Director of BioFlux Business Marketing, Fluxion – “Application of microfluidics to ion channel drug discovery and liquid biopsies for precise cancer diagnosis”

 

11:15 AM – 11:35 PM – Ander Lindqvist

Application Scientist, Sophion – “The effect of temperature on hERG channel pharmacology measured using the Qube automated patch clamp system”

 

11:35 AM – 11:55 PM – Daniel Beacham

Senior Staff Scientist, Molecular Probes Labelling and Detection, Thermo Fisher Scientific – “CultureOne Media Supplement Accelerates Functional NSC Maturation as Revealed with Improved Imaging Solutions”

 

11:55 PM – 12:20PM – Aneesh Karatt Vellatt

Senior Research Scientist, Iontas Ltd.- “KnotBodies: creating Ion channel blocking antibody by fusing knottins into peripheral CDR loops”

 

12:20 PM – 1:20 PM – Lunch

 

1:20 PM – 2:30 PM – PM Session Panel Discussion

 

– Break into Parallel Sessions-

 

-Precision Medicine Session-

 

PM Session: Liquid Biopsy and Molecular Diagnostics

 

2:35 PM – 2:40 PM – Chair: David Weitz

Professor, Mallinckrodt Professor of Physics and Applied Physics, Harvard University

 

2:40 PM – 3:00 PM – David Weitz

Professor, Mallinckrodt Professor of Physics and Applied Physics, Harvard University – “Droplet microfluidics for single cell studies”

 

3:00 PM – 3:20 PM – Werner Struss

Senior Research Scientist, Vancouver Prostate Centre – “Treatment outcomes and tumor loss-of -heterozygosity in germline DNA repair deficient prostate cancer

 

3:20 PM – 3:40 PM – Miguel Alcaide

Research Associate, Simon Fraser University – “Novel ultrasensitive methods for the detection and quantification of tumor-derived genetic aberrations in the “liquid biopsy” era”

 

3:40 PM – 4:00 PM – Paul Li

Professor, Department of Molecular Biology and Biochemistry Simon Fraser University – “Microfluidic Technology for Liquid Biopsy in Precision Medicine”

 

4:00 PM – 4:25 PM – Coffee Break & Posters

 

PM Session: Lab-on-a-Chip and Biotechnology

 

4:25 PM – 4:30 PM – Chair: Paul August

VP, Icagen

4:30 PM – 4:50 PM – Paul August

VP , Icagen – “Patient derived stem cells as a strategy for the in vitro evaluation of muscular dystrophy therapies”

 

4:50 PM – 5:10 PM – Anthony Bahinski

Global Head, Safety Pharmacology, GlaxoSmithKline – “Human Organs on Chips: Opportunities and Challenges for Personalized Drug Development”

 

5:10 PM – 5:30 PM – Justin Ichida

Principal Investigator, University of Southern California Stem Cell – “Identification of therapeutic targets for ALS using chemical and genetic screens on patient-derived neural cultures”

 

– End of Parallel Session-

 

6:10 PM – 9:30 PM – Boat Cruise Banquet

-Ion Channel Session-

 

IC Session: Ion Channels and Transporters in Neuroscience

 

2:40 PM – 2:45 PM – Chair: Dandan Sun

Professor of Neurology, University of Pittsburgh

 

2:45 PM – 3:05 PM – Shan Ping Yu

Professor of Anesthesiology, Emory University School of Medicine – “Optogenetic stimulation of glutamatergic neuronal activity in the striatum enhances neurogenesis in the subventricular zone of normal and stroke mice”

 

3:05 PM – 3:25 PM – Kris Kahle

Professor of Neurosurgery, Yale School of Medicine – “NKCC1-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus”

 

3:25 PM – 3:45 PM – Melanie A Woodin

Associate Professor, University of Toronto – “Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition”

 

3:45 PM – 4:05 PM – Sun Dandan

Professor of Neurology, University of Pittsburgh – “WNK-SPAK/OSR1 Signaling Pathway as a Novel Target for Ischemic Stroke Therapy ”

 

4:05 PM – 4:25 PM – Giuseppe Pignataro

Associate Professor in Pharmacology, Department of Neuroscience, School of Medicine, University of Naples – “Na+/Ca2+ exchangers in neurological diseases”

 

4:25 PM – 4:45 PM – Coffee Break & Posters

 

4:45 PM – 5:05 PM – Maria Barthmes

Application Specialist, Nanion – “Targeting transporters with HTS electrophysiology: The glutamate transporter EAAT3 on the SURFE2R 96SE”

 

5:05PM – 5:25 PM – Matt Fox

CEO, Pairnomix – “Comprehensive High Throughput Drug Screening in a Cellular Model of SCN8A Epilepsy ”

 

– End of Parallel Session-

 

6:10 PM – 9:30 PM – Boat Cruise Banquet

7:55 AM – 8:25 AM – Registration

 

IC Session: Ion channels as Disease Targets

 

8:20 AM – 8:30 AM – Opening Remarks

 

Chair: Yelena Bisharyan

Director of External Alliances , Tetragenetics

 

8:30 AM – 9:00 AM Ted Clark

CSO Tetragenetics, Cornell University – “Antibodies Against Difficult to Express Ion Channel Targets”

 

9:00 AM – 9:20 AM – Robert Brenner

Associate Professor, University of Texas Health Science Center at San Antonio – “Membrane-Permeant SK Potassium Channel Antagonists are Potent Bronchorelaxants”

 

9:20 AM – 9:40 AM – Heike Wulff

Full Professor, Department of Pharmacology, University of California Davis – “Kv1.3 as a target

for inhibiting detrimental M1 microglia functions in ischemic stroke, Alzheimer’s and Parkinson’s disease”

 

9:40 AM – 10:00 AM – Brandon Brown

Associate Professor, University of Texas Health Science Center at San Antonio – “Membrane Permeant SK Potassium Channel Antagonists are Potent Bronchorelaxants”

 

10:00 AM – 10:35 AM – Coffee Break & Posters

 

IC Session: Drug Discovery

 

10:35 AM – 10:40 AM – Chair: Frederick Sachs

 

10:40 AM – 11:00 AM – Riccardo Rizzetto

Electrophysiology, Axxam – “ionChannel Optical High-content Microscope” for ligand-gated ion channels drug discovery.

 

11:00 AM – 11:20 AM – Frederick Sachs

Distinguished Professor, SUNY Department of Physiology and Biophysics – “Basic science wins: Therapy for muscular dystrophy from spider spit”

 

11:20 AM – 11:40AM Tianbo Li

Scientist, Genentech – “High-throughput technologies in the new era of ion channel study and drug discovery”

 

11:40 AM – 12:40 PM – Lunch

 

12:40 AM – 1:00 PM – Poster Session

 

IC Session: Cardiac Safety and the CiPA Initiative

 

1:00 PM – 1:05 PM – Chair: Khaled Baraket

Assistant Professor, Faculty of Pharmacy, University of Alberta

 

1:05 PM – 1:25 PM – Khaled Baraket

Assistant Professor, Faculty of Pharmacy, University of Alberta – “Atomistic Computational Models To Predict Drug-mediated Cardiotoxicity”

 

1:25 PM – 1:45 PM – Wayne Giles

Professor, University of Calgary – “Electrophysiological Properties of Heart and Articular Joint Fibroblasts”

 

1:45 PM – 2:05 PM – Haoyu Zeng

Principal Scientist, Cellular Electrophysiology & Pharmacology, Safety & Exploratory Pharmacology Dept., SALAR Division, MERCK – “Distinct Ca2+ -Handling Properties in human Induced Pluripotent Stem Cell Derived-Cardiomyocytes Revealed by Exposure to Selective Ca2+-Modulating Agents”

 

2:05 PM – 2:25 PM – Najah Abi Gerges

Scientific Director, Anabios – “Adult human primary cardiomyocyte model for the simultaneous

prediction of drug-induced inotropic and proarrhythmia risk”

 

2:25 PM – 2:55 PM – Coffee Break & Posters

 

2:55 PM – 3:15 PM – Haiyang (David) Wei

Technical Director & Group Leader, Eurofins – “Validating Cardiac Ion Channels assays on the IonFlux System for the CiPA Paradigm”

 

3:15 PM – 3:35 PM – Glen Tibbits

Professor and Chair, Biomedical Physiology and Kinesiology, Simon Fraser University – “Use of hiPSCderived cardiomyocytes to study acquired and inherited arrhythmogenesis”

 

IC Session: Ion Channels as Pain Target

 

3:35 AM – 3:40 AM – Chair: Balwant Tuana

Professor, Department of Cellular and Molecular Medicine, University of Ottawa

 

3:40 PM – 4:00 PM Gerald Zamponi

Professor and Senior Associate Dean, University of Calgary – “Deubiquitination of Cav3.2 T-type calcium channels as a new target for pain therapeutics”

 

4:00 PM – 4:20 PM – Yan Xu

Peter M. Winter Professor of Anesthesiology, Pharmacology & Chemical Biology, Physics & Astronomy, and Structural Biology, University of Pittsburgh – “NMR investigation of site-specific general anesthetic binding to the voltage-gated sodium channel NaChBac and the mechanisms of inhibition”

 

4:20 PM – 4:40 PM Jie Zheng

Professor, University of California Davis – “Activation of nociceptive ion channel TRPV1”

 

4:40 PM – 5:00 – Closing Remarks – Dong Liang,

President and CEO, Aurora Biomed, Inc.

Speakers

*Listed in no particular order

Image result for brad nelson bcca

KEYNOTE:

Brad Nelson

Director and Distinguished Scientist, Deeley Research Centre, BC Cancer Agency

Image result for alfred george northwestern university

KEYNOTE:

Alfred George

Chair, Department of Pharmacology, Northwestern University
David Rabuka

David Rabuka

Global Head of R&D, Chemical Biology, Catalent Biologics Miguel Alcaide Research Associate, Simon Fraser University
Image result for annarosa arcangeli

Annarosa Arcangeli

Professor in Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Italy Ali Yehia

Ali Yehia

VP IonFlux Product and Director of BioFlux Business Marketing, Fluxion

Charlie Cohen

VP Biology, Xenon Pharmaceuticals

Sun Dandan

Professor of Neurology, University of Pittsburgh
JP Johnson Jr.

JP Johnson

Senior Director, Cellular and Molecular Biology, Xenon Pharmaceuticals Photo of Shan Ping Yu

Shan Ping Yu

Professor of Anesthesiology, Emory University School of Medicine

Image result for isabelle deschenes case western

Isabelle Deschenes

Associate Professor, Case Western Reserve University faculty_img

Melanie A Woodin

Associate Professor, University of Toronto

Saverio Gentile

Assistant Professor, Loyola University Chicago https://az736297.vo.msecnd.net/Profile/images/1f104aa8-64a6-47d6-bbb8-fa3e09665b83_w0

Kris Kahle

Professor of Neurosurgery, Yale School of Medicine
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Eric Holland

Senior VP and Director, Fred Hutchinson Cancer Research Center Image result for giuseppe pignataro naples

Giuseppe Pignataro

Associate Professor in Pharmacology, Department of Neuroscience, School of Medicine, University of Naples
Neil Castle

Neil Castle

VP Research, Icagen Image result for maria barthmes

Maria Barthmes

Application Specialist, Nanion
Paul August

Paul August

VP, Icagen Dr. Ted Clark

Ted Clark

CSO Tetragenetics, Cornell University
Image result for Vincenzo Carnevale temple

Vincenzo Carnevale

Research Associate Professor, Temple University Image result for Robert Brenner texas

Robert Brenner

Associate Professor, University of Texas Health Science Center at San Antonio
Image result for yan xu

Yan Xu

Professor of Anesthesiology, Pharmacology, and Structural Biology, University of Pittsburgh Image result for heike wulff

Heike Wulff

Associate Professor, Department of Pharmacology, University of California, Davis
Image result for anthony bahinski

Anthony Bahinski

Global Head, Safety Pharmacology, GlaxoSmithKline Brandon M. Brown

Brandon Brown

Post Doctoral Fellow, University of California, Davis
http://ichidalab.usc.edu/files/2013/10/Justin-Ichida-by-Cristy-Lytal-crop-285x285.jpg

Justin Ichida

Principal Investigator, Stem Cell Research, University of Southern California Image result for Zhiyuan Li principal investigator

Zhiyuan Li

Principal Investigator, Guangzhou Institutes Of Biomedicine And Health
Image result for Ashleen Shadeo

Ashleen Shadeo

Sector Manager, Health, Genome BC https://media.licdn.com/mpr/mpr/shrinknp_200_200/AAEAAQAAAAAAAAOEAAAAJGI3MWYzM2U1LWYxMDgtNDE5OS05ZDdjLTFlNGZjNmFkODQwMQ.jpg

Riccardo Rizzeto

Electrophysiology, Axxam
Tao Chen

Tao Chen

CEO, Paragon Genomics Frederick Sachs

Frederick Sachs

Distinguished Professor, State University of New York, Department of Physiology and Biophysics
Amit Mahipal

Amit Mahipal

Associate Professor, Mayo Clinic NGS Image result for Tianbo Li

Tianbo Li

Scientist, Genentech San Francisco
Image result for Gourab Bhattacharjee illumina

Gourab Bhattacharjee

Marketing Programs Manager, Oncology, Illumina Image result for Khaled Barakat

Khaled Barakat

Assistant Professor, Faculty of Pharmacy, University of Alberta
Image result for blank profile picture

Ander Lindqvist

Application Scientist, Sophion Wayne Giles Professor, University of Calgary
Image result for Daniel Beacham thermo fisher

Daniel Beacham

Senior Staff Scientist, Molecular Probes Labelling and Detection, ThermoFisher Scientific Haoyu Zeng photo

Haoyu Zeng

Principal Scientist, Cellular Electrophysiology & Pharmacology, Safety & Exploratory Pharmacology Dept., SALAR Division, Merck & Co.
Image result for matthew fox pairnomix

Matt Fox

CEO, Pairnomix Dr Najah Abi-Gerges

Najah Abi Gerges

Scientific Director, Anabios
Image result for David Weitz

David Weitz

Professor, Mallinckrodt Professor of Physics and Applied Physics, Harvard University Haiyang Wei

David Wei

Eurofins
https://i1.rgstatic.net/ii/profile.image/AS%3A279839241195541%401443730282851_l/Werner_Struss.png

Werner Struss

Senior Research Scientist, Vancouver Prostate Centre Image result for gerald zamponi

Gerald Zamponi

Professor and Senior Associate Dean, Unversity of Calgary
Jie Zheng, Ph.D.

Jie Zheng

Professor, University of California, Davis Image result for jeffrey herz algomedix

Jeffrey Herz

CEO, Algomedix
Bryan Moyer

Bryan Moyer

Principal Scientist, Amgen Image result for christopher triggle

Christopher Triggle

Professor, Department of Pharmacology, Weill Cornell Medicine, Qatar
Ester Falconer

Ester Falconer

Senior Scientist, Abcellera image005.jpg

Glen Tibbits

Professor and Chair, Biomedical Physiology and Kinesiology, Simon Fraser University

Aneesh Karatt Vellatt

Senior Research Scientist, Iontas Ltd Paul Li  Professor, Department of Molecular Biology and Biochemistry Simon Fraser University

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