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Precision Medicine & Ion Channel Retreat 2018

16th Annual Ion Channel Retreat

PMICR 2018 Logo Jpeg

This year, co-hosted with the Guangzhou Institute of Biomedicine and Health (GIBH) Chinese Academy of Sciences, Peking University, Hebei University of Technology and our Organizing Committee (OC), the 2018 Precision Medicine and Ion Channel Retreat will be held November 14th – 16th, 2018, in Guangzhou, China. 

Since our inaugural meeting in 2003, the Retreat has evolved to become one of the most reputable events within the ion channel drug discovery community. For our 15th Annual Retreat, we decided to bring the meeting back to beautiful Vancouver, Canada. We gathered new speakers to discuss the latest trends in Precision Medicine, and hosted an interdisciplinary panel discussion, forging the need for collaboration within the ion channel space, and into the larger framework of Precision Medicine.

On the Ion Channel side, we incorporated new disease targets, as speakers introduced creative ways, and new techniques with the latest technology in the field. We had a parallel session as well, that included new topics of ion transporters, various channelopathies, and CiPA related cardiac toxicity.

We added new topics to the Precision Medicine section, including immunotherapy, liquid biopsies, clinical applications of NGS, and our interdisciplinary session on novel perspectives of ion channels in Precision Medicine, within the broader scope of drug discovery.

For 2018, with the expanding developments in the Asia Pacific, we are happy to bring forward new ventures for this year’s Retreat in Southern China.

 We welcome your feedback, and any questions you may have. At this moment, we are receiving Abstracts, and you may contact us at the following –

For general inquiries, contact – retreat@aurorabiomed.com

Topics

Precision Medicine Session

  1. Novel Perspective of Ion Channels in Precision Medicine
  2. Molecular Diagnostic Technologies
  3. Cancer Diagnosis and Treatment
  4. Liquid Biopsy in Oncology
  5. Liquid Biopsy for Clinical Practice
  6. Immunotherapy: emerging applications and challenges
  7. Applications of Next Generation Sequencing
  8. Microarray and Biotechnology

Ion Channel Session

  1. Ion Channel Structure and Function
  2. Ion Channels as Disease Targets
  3. Ion Channels as Pain Targets
  4. Drug Development
  5. Screening Technologies
  6. Cardiac Safety and the CiPA Initiative
  7. Ion Transporters in Pathogenesis
  8. Ion Transporters in Drug Discovery

Program Schedule

Program Schedule

 

14th November 2018

 

8:00 AM – 10:00 AM – Registration

10:00 AM – 10:05AM – Opening Remarks: Aurora Biomed Inc.

10:05 AM – 10:15AM – Welcoming Remarks: Shunde Government

10:15 AM – 10:25AM – Welcoming Remarks: Senior Trade Commissioner & Canadian Consulate

10:25 AM – 10:30AM – Welcoming Remarks: Shunde Government

 

Keynote Presentation

10:35 AM – 11:15AM – Andre Ghetti

CEO of AnaBios Corperation – Novel Strategies for Translational Research in Pain Drug Discovery

 

IC Session:

11:15 AM – 11:45 AM – Xi Huang

Principal Investigator,The Arthur and Sonia Labatt Brain Tumour Research Centre- “From fly to mammal: targeting ion channels in brain tumor

 

11:45 AM – 12:05 PM – Wen Yang

Principal Associate, Roche – “Development of an ion flux assay & HTS campaign for modulators of a cation-chloride co-transporter

 

12:05 PM – 1:30 PM – Lunch

 

Parallel Sessions begin

 

-Start of Parallel Session 1-

 

PM Session: Precision drug research and development

1:30 PM – 1:35 PM – Chair: Hailong An

Hebei University of Technology

 

1:35 PM – 1:55 PM – Hailong An

Hebei University of Technology– “Identification of the calcium-dependent gating and targeted-drug discovery of CaCCs”

 

1:55 PM – 2:15 PM – Erika Piedras-Renteria

Loyola University Chicago– “Leptin-induced hypothalamic excitability is mediated by a TRPC-Cav3 complex”

 

2:15 PM – 2:35 PM – Wei Yang

Zhejiang University– “TRPM2 Channel: New drug target for treating brain ischemia”

 

2:35 PM – 3:05 PM – Coffee Break & Posters

 

PM Session: Novel Targets in Oncology Diagnosis & Treatment

3:05 PM – 3:10 PM – Chair: Saverio Gentile

University of Illinois at Chicago

 

3:10 PM – 3:30 PM – Saverio Gentile

University of Illinois at Chicago– “Cancer vulnerability unveiled by targeting ion channels: A novel discovery and therapeutic approach”

 

3:30 PM – 3:50 PM – Cesare Sala

University of Florence – “The ion channel and transporters gene expression profile indicates a shift in excitability and metabolisms during malignant progression of Follicular Lymphoma”

 

3:50 PM – 4:10 PM – Qinghuan Xiao

China Medical University School of Medicine– “TMEM16A inhibition represents a novel therapy for breast cancer with EGFR expression”

 

4:10 PM – 4:30 PM – Anna Borgstroem

Transcure, Bern University – “Investigation of TRPM4 and its Role in Cell Migration and Proliferation of Prostate Cancer Cells”

 

-End of Parallel Session 1-

 

-Start of Parallel Session 2-

 

IC Session: Biology Drug – A Potential Therapeutic for Ion Channel Targets

1:30 PM – 1:35 PM – Chair: George Chandy

Nanyang Technological University

 

1:35 PM – 1:55 PM – George Chandy

Nanyang Technological University – “Immunomodulatory peptides from edible plants”

 

1:55 PM – 2:15 PM – Yan Nian

Kunming institute of zoology – “Discovery of Novel Natural Products Targeting Ion Channels”

 

2:15 PM – 2:35 PM – Paul Li

Simon Fraser University – “Activation of TRPV2 on a single glioblastoma cell measured in a microfluidic biochip”

 

2:35 PM – 3:05 PM – Coffee Break & Posters

 

IC Session: Human induced pluripotent stem cell-derived cardiomyocytes: From cardiac safety to disease modeling

3:05 PM – 3:10 PM – Chair: Marc Pourrier

IonsGate Preclinical Services Inc

 

3:10 PM – 3:30 PM – Marc Pourrier

IonsGate Preclinical Services Inc– “Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) to model arrhythmogenic diseases”

 

3:30 PM – 3:50 PM – Ronald Li

Novoheart– “Engineering Mini Human Heart Chambers for Drug Discovery and Disease Modeling”

 

3:50 PM – 4:10 PM – Robert Kass

Columbia University– “Patient-specific induced pluripotent stems as a platform for precision therapeutics in the treatment of an inherited cardiac arrhythmia”

 

4:10 PM – 4:30 PM – Haiheng Dong

Wuxi. Apptech– “The application of human-induced pluripotent stem cell-derived ventricular cardiomyocytes generated in the chemical-defined and albumin-free condition (CaulisCells) in the MEA cardiac safety assessment”

 

-End of Parallel Session 2-

 

4:30 PM – 4:40 PM – 10 minute break

 

Investment Workshop

4:05 PM – 3:10 PM – Chair: Wayne Tan

Executive Director of HK Bio-Med Innotech Association

 

4:45 PM – 6:30 PM

 

VIP Dinner

6:30 PM – 9:00 PM

 

 

15th November 2018

 

8:25 AM – 8:30 AM – Welcome & Opening Remarks + Chair of keynote speech: Andre Ghetti

 

Keynote Presentation

8:30 AM – 9:10 AM – David Smith

Mayo Clinic- “What is the $100 Genome and why is it such a big deal”

 

Aurora Biomed Presentation

9:10 AM – 9:40 AM – Dong Liang

Aurora Biomed- “Ion Channels Targeted and Anti-Cancer Drug Discovery”

 

Peptide Array

9:40 AM – 10:00 AM – Myriame Gabay

Biomime Solutions- “Peptide arrays for drug discovery”

 

10:00 – 10:40 – Coffee Break & Posters

 

-Start of Parallel Session 1-

 

PM Session: Novel Targets in Oncology Diagnosis & Treatment

10:40 AM – 10:45 AM – Chair: Annarosa Arcangeli

University of Florence

 

10:45 AM – 11:05 AM – Chair: Annarosa Arcangeli

University of Florence- “Ion channels in Cancer: from molecular devices to therapeutic targets”

 

11:05 AM – 11:25 AM – Navin Verma

Nanyang Technological University – “Overriding ‘ionic-checkpoint’: A new strategy to boost antitumour responses of T lymphocytes

 

11:25 AM – 11:45 PM – N. Prevarskaya

University of Lille, France – “Calcium and calcium channels in initiation and progression of prostate cancer

 

11:45 AM – 12:05 PM – Luigi Leanza

University of Padova, Italy – “Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo

 

12:05 PM – 1:05 PM – Lunch

 

PM Session: Advances of cancer complementary diagnostics and precision therapy

1:05 PM – 1:10 PM – Chair: Frank Fan

 

1:10 PM – 1:30 PM – Jodie Tang

Zhuhai Livzon Cynvenio Diagnostics Ltd – “Liquid Biopsy: Connecting the missing links of precision medicine in cancer”

 

1:30 PM – 1:50 PM – Danyi Wen

LIDE Biotech – “Functional Diagnostics and RWE in Cancer Precision Medicine”

 

1:50 PM – 2:10 PM – Rudy Zhao

Promega – “Application of Microsatellite Instability Analysis in Cancer Diagnosis and Treatment”

 

PM Session: Novel Tools/Methods to Forensic Sciences & Human Identification

2:10 PM – 2:15 PM – Chair: Helena Wong

Oakland Police department, USA

 

2:15 PM – 2:35 PM – Helena Wong

Oakland Police department, USA– “Automated Differential Digestion using the VERSA 1100”

 

2:35 PM – 2:55 PM –

AGCU ScienTech Incorporation– “The application of new products in human identification in challenging cases”

 

2:55 PM – 3:15 PM – Shujin Li

College of Forensic Medicine Hebei Medical University– “Screening of high-effective DNA methylation markers for discriminating monozygotic twins”

 

-End of Parallel Session 1-

 

-Start of Parallel Session 2-

 

IC Session: The development of anti-tumor drug

10:40 AM – 10:45 AM – Chair: Xi Huang

The Hospital for Sick Children, Toronto

 

10:45 AM – 11:05 AM – Roger Abounader

University of Virginia– “Role and therapeutic targeting of T-type calcium channels in glioblastoma”

 

11:05 AM – 11:25 AM – Juri Reimand

Ontario Institute for Cancer Research– “Integrative analysis of pan-cancer genomics datasets reveals prognostic and functional oncochannels”

 

11:25 AM – 11:45 AM – Chi-chung Hui

The Hospital for Sick Children, Toronto– “GLI2-regulated ion-channel genes as potential targets of SHH medulloblastoma”

 

11:45 AM – 12:05 PM – Rongqi Huang

GIBH – “Thermal stress promote tumorigenesis in ESCC via TRPV2-dependent pathway”

 

12:05 PM – 1:05 PM – Lunch

 

IC Session: Emerging Areas of Ion Transporter Research

1:05 PM – 1:10 PM – Jinwei Zhang
University of Exeter

 

1:10 PM – 1:30 PM – Dandan Sun
University of Pittsburgh – “Ion transporters in glioma cancer”

 

1:30 PM – 1:50 PM – Jinwei Zhang
University of Exeter – “KCC2 ion transporter as a novel therapeutic target for epilepsy”

 

1:50 PM – 2:10 PM – Xianming Deng
School of Life Sciences, Xiamen University – “Pharmacological validation of new kinases with small molecules”

 

IC Session: Ion Channels Screening Technologies

2:10 PM – 2:15 PM – Andrea Bruggemann
Nanion Technologies GmbH

 

2:15 PM – 2:35 PM – Andrea Bruggemann
Nanion Technologies GmbH – “Opening up new opportunities by combining high throughput electrophysiology with optical tools”

 

2:35 PM – 2:55 PM – Shouming Du
Hammatsu – “Case studies: An outsider’s view on phenotypic screening to target identification with a focus on high throughput tools related to ion channels”

 

-End of Parallel Session 2-

 

3:15 PM – 3:30 PM – Coffee Break & Posters

 

Panel Discussion

3:30 PM – 4:30 PM

 

Boat Cruise + Dinner

4:30 PM – 9:30 PM

 

November 16th, Friday

 

-Start of Parallel Session 1-

 

PM Session: Applications & Advancement of NGS

9:00 AM – 9:05 AM – Chair: Hui Jiang
BGI

 

9:05 AM – 9:25 AM – Hui Jiang
BGI – “The application of MGI Sequencers on oncology test”

 

9:25 AM – 9:45 AM – Issac Garcia- Murillas
The Institute of Cancer Research – “Clinical utility of circulating tumour DNA analysis in hormone receptor positive breast cancer patients”

 

9:45 AM – 10:05 AM – Xingfei Deng
Ardent Biomed Guangzhou Inc.

 

10:25 AM – 10:55 AM – Coffee Break & Posters

 

IC Session: Structure and Function of Ion Channels

10:55 AM – 11:00 AM – Chair: Henry Colecraft
Columbia University

 

11:00 AM – 11:20 AM – Bailong Xiao
Tsinghua University – “Structure & mechanogating mechanism of the mechanosensitive Piezo1 channel”

 

11:20 AM – 11:40 AM – Shiqing Cai
Institute of Neuroscience Chinese Academy of Sciences – “The mechanism underlying protein biogensis of the hERG channel and pharmacological rescue of LQTS mutant channels”

 

11:40 AM – 12:00 PM – Henry Colecraft
Columbia University – “Design and application of genetically-encoded ion channel modulators”

 

12:00 PM – 12:20 PM – Panpan Hou
Washington University – “A non-canonical VSD-pore coupling in KCNQ channels”

 

-End of Parallel Session 1-

 

-Start of Parallel Session 2-

 

IC Session: Ion Channels as Pain Targets

9:00 AM – 9:05 AM – Chair: Guangyin Xu; Andre Ghetti
Suzhou University

 

9:05 AM – 9:25 AM – Guangyin Xu
Suzhou University – “Epigenetic regulations of purinergic receptors in various pain conditions”

 

9:25 AM – 9:45 AM – Joel Castro
Head of Colon Research, Visceral Pain Group (VIPER) – “Contribution of membrane receptors to visceral pain sensation”

 

9:45 AM – 10:05 AM – Lunbin Deng
Genentec – “Making novel pain drugs by selectively targeting Nav1.7”

 

10:05 AM – 10:25 AM – Xian-Ping Dong
Dalhousie University – “Regulation of MTORC1 by the lysosomal Ca2+ channel TRPML1/mucolipin-1 in cellular homeostasis and human diseases”

 

10:25 AM – 10:55 AM – Coffee Break & Posters

 

IC Session: Ion Channels as Disease Targets

10:55 AM – 11:00 AM – Chair: Zhuo Huang
Peking University

 

11:00 AM – 11:20 AM – Zhuo Huang
Peking University – “ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice”

 

11:20 AM – 11:40 AM – Christopher Donald Makinson
Stanford University: School of Medicine – “Targeting voltage gated sodium channels for the treatment of epilepsy”

 

11:40 AM – 12:00 PM – Weiping Wang
IMM – “Discovery of Kv2.1 potassium channel selective blocker for neuroprotection”

 

IC Session: Structure and Function of Ion Channels

12:00 AM – 12:20 PM – Jing Li
Guangzhou University of Chinese Medicine – “Mechanosensitive ion channel protein Piezo1in vascular biology”

 

-End of Parallel Session 2-

 

12:20 PM – 12:30 PM – Closing Remarks

 

12:30 PM – 1:30 PM – Break + Lunch

 

Visit & Study Section

1:30 PM – 6:00 PM – Sino-Euro Center, Aurora Scientific park

Testimonials from the 2017 Meeting

Past Attendees

  • Craig January, MD, PhD – Professor at the School of Medicine and Public Health, at the University of Wisconsin
  • William Catterall, PhD – Professor and Chair of University of Washington Department of Pharmacology
  • Arthur Brown, PhD – CEO of MemChan; former founder & CEO of ChanTest
  • Yuko Sekino, PhD – Director of Pharmacology National Institute of Health Sciences, Japan
  • Edward Stevens, PhD – Head of Electrophysiology at Pfizer, Cambridge, UK
  • Dennis Lo, MD, PhD – Associate Dean, Faculty of Medicine at CUHK, Foreign Associate US Academy of Sciences
  • George Chandy, MD, PhD – Professor at NTU SG and UC Irvine
  • Kurt Stoeckli President & CSO at Glenmark Pharmaceuticals, Switzerland
  • Hailin Zhang, MD, PhD – Vice President of Hebei Medical University
  • Richard Olsen, PhDDistinguished Professor of Neuroscience at the David Geffen School of Medicine at UCLA
  • Yuklam Lo Secretariat, and Honorary Chairman, Hong Kong Biotechlogy Organization
  • An Hailong Hebei University of Technology; Professor
  • Dan Minor, PhD – Professor, Biochemistry and Biophysics, Cellular and Molecular Pharmacology, University of California
  • Steve Goldstein, MD, PhDDirector at the Institute of Pediatric Sciences, University of Chicago
  • John Dunlop, PhD VP, Neuroscience Research at Amgen, Professor of Neuroscience, University of St Andrews
  • Laszlo Urban, MD, PhD – Executive Director at Novartis
  • Jean-Pierre Valentin, PhD – Senior Director, Head of Investigative Toxicology at UCB

Ramada Plaza Shunde

2 Linshang Road, Beijiao Town, Shunde District
Foshan City, Guangdong Province, China

Tel: +86 (757) 2239 8888

http://www.ramada.com

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