Vancouver BC, Canada • June 28 – 30, 2010
Hyatt Regency Hotel, Vancouver
Speaking Program (Subject to Change)
June 28th, 2010
8:00 am – Registration and Breakfast
8:50 am – Welcome & Opening Remarks Saranna Brugger - Program Coordinator
Aurora Biomed
Session 1: Ion Channels as Disease Targets
8:55 – Chairperson's Remarks John Dunlop
Executive Director
Pfizer
9:00 - 9:25 Modes of action of a7 nicotinic receptors John Dunlop
Executive Director
Pfizer
9:30 - 9:55 Development of investigational ion channel modulators of mutant CFTR for the treatment of cystic fibrosis Fredrick VanGoor
Research Fellow II
Vertex Pharmaceuticals
10:00 – Chairperson's Remarks Alan Wickenden
Research Fellow
Johnson & Johnson PRD
10:05 - 10:30 Sodium Channels as Pain Targets Birgit Priest
Senior Research Fellow
Merck Research Laboratories
10:35 - 10:50 Coffee Break - Meeting Foyer
10:55 - 11:20 The role of gap junctions in neuropathic pain Jianguo Cheng
Staff Physician
Cleveland Clinic
11:25 - 11:50 Drug discovery using a panel of NaV1.7 cell lines comprising alpha and beta subunits resulted in potent analgesics Kambiz Shekdar
CSO
Chromocell Corporation
14:05 - 14:30 Design of a highly selective small-molecule inhibitor of the renal outer medullary potassium channel (ROMK) Jerod Denton
Assistant Professor
Vanderbilit University
14:55 Chairperson's Remarks Alan Wickenden
Research Fellow
Johnson & Johnson PRD
15:00 - 15:25 The Sensory Irritant Receptor TRPA1 is essential for airway inflammation and hyperreactivity in asthma Sven-Eric Jordt
Assistant Professor
Yale University of Medicine
15:30 - 15:55 Pharmacology and Function of Cold-Activated Trpm8 Channels Felix Viana de la Iglesia
Tenured Investigator CSIC
Universidad Migueul Hernandez
16:00 - 16:25 TRPV6 is the focus for a targeted management of ovarian cancer: early detection and treatment. Jack Stewart
Chief Scientific Officer
Soricimed Biopharma Inc.
8:30 am – Opening Remarks Saranna Brugger - Program Coordinator
Aurora Biomed
Session 5: Ion Channel Screening Technologies
8:35 – Chairperson's Remarks Alan Wickenden
Research Fellow
Johnson & Johnson PRD
8:40 - 9:05 Introduction to the IonWorks Barracuda System: An Automated Electrophysiology Platform for Measuring Ligand- or Voltage-gated Channels Simultaneously in 384 Wells Xin Jiang
Application Scientist
Molecular Devices Inc.
9:10 - 9:35 Development of an HTS Flux Assay for TRP Channels using ICR8000 Sikander Gill
Application Scientist & Senior R&D
Aurora Biomed
9:40 - 10:05 Excitement over Automated Patch Clamp: heat activation of trpv1 and action potentials of cardiomyocytes Rodolfo Haedo
General Manager
Nanion Technologies Inc
12:35 - 13:00 hERG in silico 3D Modelling to Guide Compound Development in a Histamine H3 Receptor Antagonist program Andreas Ebneth
Group Leader In Vitro Neurobiology
Evotec
13:05 - 13:30 Evolving strategic options for ion channel discovery research Andrew Southan
Director, Ion Channel Biology
Biofocus
13:35 - 14:00 Cardiomyocytes for Advanced Electrophysiological Drug Screening: Comparison of Mouse ES and Human iPS Cell-derived Cells Ralf Kettenhofen
Senior Scientist
Axiogenesis AG
14:25 - 14:50 Development of a high throughput IonFlux assay to detect positive allosteric modulators of the GABAA receptor Speaker for Fluxion Biosciences
Juha Kammonen
Pfizer Global Research & Development
14:55 - 15:20 Application of a novel patch-clamp chip interface to cultured neurons Marzia Martina
Research Officer
National Research Council of Canada
17:00 – Meet in Hyatt lobby for boat cruise
17:30 - 21:30 – Boat cruise sponsored by Millipore.
9:10 - 9:35 How do hERG channels activate? Insight from gating currents and tetramethylrhodamine fluorescence David Fedida
Professor & Associate Head
University of British Columbia
9:40 - 10:05 The voltage sensor of Iks channels may be an ideal drug target in the prevention of cardiac arrhythmias Dick Wu
Professor
Washington University in St. Louis
11:00 Chairperson's Remarks Gul Erdemli
Head of Ion Channel Group
Novartis
11:05 - 11:30 Novel Approaches in Targeting Ion Channels James Prudent
Centrose
President & CEO
11:35 - 12:35 Lunch - Served in Foyer / Meeting Room
12:40 - 13:05 8-pCPT-cGMP is a potent epithelial Na channel opener Hong-Long (James) Ji
Associate Professor
University of Texas Health Science Center
13:10 - 13:35 Ion Channels Properties of Motor neurons Differentiation from iPSCs Zhiyuan Li
Principal Investigator
Guangzhou Institute of Biomedicine and Health
13:40 - 14:00 Closing Remarks Dong Liang
President & CEO
Aurora Biomed
Identification of C-terminal basic residues involved in the chemical and voltage-dependent activation of TRPA1 Lucie Sura
PhD Student
Academy of Sciences; Czech Republic
Homology modelling and molecular dynamics simulations of ion channels from TRP family Vlastimil Zima
PhD Student
Charles University; Prague
Identification and Characterization of Natural and Synthetic Inhibitors of Receptor Operated Cation Channel, TRPC6 Sanjay Danthi
Staff Scientist II
GenZyme
GRC17536 - a novel, potent, selective and orally effective TRPA1 antagonist as a clinical lead for potential treatment of chronic inflammatory and neuropathic pain Indranil Mukhopadhyay
Principal Scientist
Glenmark Pharmaceuticals Ltd.
High Expression of TRPV1 in Mammalian Cells Rong Xia
Postdoc
Astrazeneca
June 29th, 2010
Enabling Ion Channel Screening through Improved Reagent Provision Alexandra Alderton
Principal Scientist
Pfizer Global R&D
Validation of a high throughput twin pore potassium channel assay in the absence of selective tools Juha Kammonen
Senior Scientist
Pfizer
Off target drug effects— mechanisms of and screening for amphiphile regulation of ion channel function through changes in lipid bilayer properties Ruchi Kapoor
PhD Candidate
Weill Cornell Medical College
Dielectrophoresis-Based Single Cell Shuttling For Multi-Drug Resistance Study Yuchun Chen
PhD Candidate
Simon Fraser University
Non-invasive MIFE ion flux measurements in ion channels research Sergey Shabala
A/Professor
University of Tasmania
June 30th, 2010
Possible mediation of gentamycin uptake of MDCK cells via Connexin 43 hemichannels Zhi-Gen Jiang
Associate Professor
Oregon Health & Science University
Cellular mechanism of the QT prolongation induced by sertraline Hyang-Ae Lee
Research Scientist
Korea Institute of Toxicology
The SecY protein translocation channel is capable of ionic discrimination Kush Dalal
PHd Student
University of British Columbia
The regulation of N-type (Cav2.2) voltage-gated calcium channels by Cav subunit N- and C-terminal variable domains Lele Song
Postdoctoral Fellow University of Manchester
Interactions between agonists and CNG channels producing bimodal agonism Wai Wong
BSc Candidate - Molecular Biology and Biochemistry
Simon Fraser University
For more information regarding the 2010 Ion Channel Retreat Speaking Program, please contact us at retreat@aurorabiomed.com
8:55 – Chairperson's Remarks
