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(HP-5-Extra info) Ion Channel Reader 12000

(HP-5-Extra info) Ion Channel Reader 12000

Publications & Application Notes

• Cellular HTS Assays for Pharmacological Characterization of NaV1.7 Modulators

• High-Throughput Screening Assay for Acid-Sensing Ion Channels

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Frequently Asked Questions

The non-radioactive flux assay is considered a high throughput solution to investigate a broad range of membrane proteins including electro-neutral targets, to which conventional electrophysiology cannot be applied. The flux assay is capable of establishing the same drug potency rank orders as patch clamps.

Membrane protein targets including voltage-gated and ligand-gated ion channels, co-transporters and pumps.

Cells expressing the ion channels of interest go through a protocol of tracer loading, drug incubation, wash, treatment, and lysis before they are be fed into the ICR. The ICR can fully automate the sample analysis procedure.

The minimal sample loading volume is for 50ul for the ICR 8000 and 20ul for the ICR 12000. The ICR 12000 has a throughput of processing 60000 wells/day as compared to 5000 wells/day on the ICR 8000. The ICR 12000 also has an optional plate stacker.

Standard 96 and 384 well plates.

Our customers include Amgen, Merck, AstraZeneca, Roche, Pfizer, University of British Columbia, Heibei Medical University, and more.