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Automated Solid Phase Extraction (SPE) System


    VERSA automated Solid Phase Extraction systems (also known as automated SPE systems) fully automate SPE workflows from cartridge conditioning to sample derivatization. With the combination of the ReagentDrop™ dispenser, Heater-Shaker, Gripper, and Nitrogen Dryer, VERSA automated solid phase extraction (SPE) systems act to produce contamination-free sample pre-processing and trace analyte enrichment before performing sample analysis by a chromatography-based platform (HPLC, GCMS, HPLC-MS, etc).

    The VERSA line of automated SPE systems are highly scalable for different throughputs and budgets. From the compact VERSA 10 to the highly customizable VERSA 1100, they can boost productivity in applications ranging from forensics, environmental samples, pharmaceutical compound analysis (ADME), metabolomics, and food safety.

    Independently Validated

    Dr. Thiangthum and Dr. Tanunkat from Bureau of Drug and Narcotic of Thailand use the VERSA 1100 automated Solid Phase Extraction system to quantify amphetamine and methamphetamine in drug users. They test more than 100,000 urine samples with VERSA automated SPE workstation each year.

    Download the validation poster to see how the VERSA 1100 automated Solid Phase Extraction system is eliminating cross-contamination while ensuring accuracy and reproducibility in urine samples of drug users.

    Modules Tailored for your Entire Automated SPE Workflow

    Compatibility with Different Commercial Cartridges

    1,  3,  6 mL  Cartridges   &  96 SPE  Cartridge Plates

    Current Gripper


    moves cartridge block and nitrogen dryer for on-deck washing, elution, drying, and derivatization


    allows efficient sample pre-processing and derivatization, streamlines complete automated SPE workflow

    Vacuum Manifold (Negative Pressure)

    ensures samples and reagents flow through cartridges efficiently

    Nitrogen Dryer

    enables on-deck sample drying/concentration prior to reconstitution/derivatization

    Reagent Block Cooler

    cools reagents for derivatization

    Positive Pressure Module for VERSA Automated Solid Phase Extraction System

    Positive Pressure Module

    ensures samples and reagents flow through cartridges efficiently


    dispenses reagents from off-deck reservoirs and eliminates tip usage – prevents dripping of volatile solvents

    SPE Cartridge Holder

    works with the Gripper to automate conditioning, loading, washing, eluting, and fraction collecting steps

    • Capable of performing Automated Liquid Liquid Extraction on the same workstation (VERSA 1100)
    • Compatibility with organic and aqueous reagents
    • Exhaust system available to remove volatile organic fumes
    • HEPA/UV/LED Enclosure – keeps samples contamination-free
    • Unparalleled Customer Service – our engineering team is readily available to troubleshoot your protocols


    VERSA 1100 Automated Solid Phase Extraction (SPE) System

    Deck Capacity15
    Pipetting Head

    (Single Channel Function, Disposable Tip)

    4 or 8 channel
    ReagentDropup to 8
    Supported Cartridges1, 3 or 6 mL cartridges or 96 SPE cartridge plate
    Pressure Module(s)4 channel positive pressure module and/or vacuum manifold (negative pressure)
    Nitrogen Dryer24 or 96 channels
    Shaker-Heater (2400rpm, RT to 90°C)Optional
    Reagent Block CoolerOptional
    Liquid Level SensingOptional for Liquid Liquid Extraction
    HEPA/UV/LED EnclosureIncluded
    Width x Depth x Height (cm)99 x 75 x 90
    Weight (kg)162

    Applications – VERSA Automated Solid Phase Extraction Systems

    • Food Safety
    • Vitamin D from Blood/Serum Samples
    • Drugs of Abuse in Forensic Analysis
    • Compounds for Drug Discovery
    • Iso-Flavonoides from Urine Samples
    • Aflatoxins from Seafood Products
    • Growth Promoters in Blood
    • Semi-Volatile or Non-Volatile Analytes
    • Protein Precipitation

    Frequently Asked Questions

    Solid phase extraction (SPE) is a technique for sample preparation using solid adsorbent contained in either a cartridge (column), a disk or a plate (for automated SPE only). Manual workflow of SPE can be time-consuming and prone to human-errors, while VERSA Automated Solid Phase Extraction (SPE) workstations fully automate SPE workflow from sample preparation and cartridge conditioning to sample derivatization on a single deck through the use of innovative, flexible modules. The combination of a Shaker-Heater, Nitrogen Dryer, and Gripper enables a complete walk-away solution for any SPE protocol including reconstitution of dried samples.

    SPE is mainly used to  prepare samples  for analyzing on Mass Spectrometry platform or chromatography-based platform (HPLC, GCMS, HPLC-MS, etc.) with a range of applications from metabolomics, forensics, environmental samples, pharmaceutical compound analysis (ADME), and food safety;

    VERSA is compatible with 1 mL, 3 mL, and 6 mL cartridges, in addition to 96-well SPE cartridge plates.

    VERSA is equipped with either a 4 or 8 channel disposable tip syringe pipettor with single channel functionality, providing increased versatility and preventing cross-contamination.

    Yes, the VERSA automated SPE workstation is capable of performing automated Liquid-Liquid Extraction on the same workstation. VERSA is highly scalable for different applications, throughputs, and budgets.

    Yes, the VERSA Automated Solid Phase Extraction (SPE) workstation is equipped with a nitrogen dryer block that can be used for solvent evaporation and sample concentration after collection. Reconstitution in the organic or aqueous solvent of your choice can be easily conducted with the use of the ReagentDrop.

    a. For ReagentDrop – most organic solvents are compatible (tubing is PTFE, check here for compatibility https://www.coleparmer.com/chemical-resistance) – avoid concentrated aqueous solutions (salting out could clog the tubing) and concentrated acids or bases (can degrade metal components)

    b. For pipetting and solutions on deck – avoid very volatile solvents (instead, have them on the RD) and any concentrated acids or bases (fumes can degrade instrument components).

    1. Pipette maximum aspiration/dispensing volume is 1000uL.
    2. Maximum samples handling volume is around 10-15 mL

    We can offer a steel-pin system (4 or 8-channel, up to 1000 uL) system for your applications.

    Get more information on the VERSA Automated Solid Phase Extraction Workstations:

    Please give us more details regarding your project for us to assist you better.