---
title: "Automated Solid-Phase Peptide Synthesis – VERSA™ Spotter"
description: "Automated solid-phase peptide synthesis involves linking of multiple amino acids via peptide bonds for the production of peptides. This process mimics the biological process of producing long peptides (proteins). In solid-phase peptide synthesis (SPPS), the peptide is 'immobilized' on a…"
url: "https://www.aurorabiomed.com/resources/solid-phase-peptide-synthesis/"
updated: "2023-08-04"
category: Liquid Handling / Application Notes / General
---

# Automated Solid-Phase Peptide Synthesis – VERSA™ Spotter

Automated solid-phase peptide synthesis involves linking of multiple amino acids via peptide bonds for the production of peptides. This process mimics the biological process of producing long peptides (proteins). In solid-phase peptide synthesis (SPPS), the peptide is 'immobilized' on a solid surface and can be retained during washing of liquid-phase reagents and synthesis by-products. Solid-phase peptide synthesis also allows the synthesis of natural peptides which are difficult to express in bacteria, the incorporation of unnatural amino acids, and peptide/protein backbone modification. In addition this process permits the synthesis of D-proteins generating extremely high yield in each step and provides a solution problems associated with sequence dependent synthesis.

Aurora’s [VERSA Microarray Printer](https://www.aurorabiomed.com/microarray-spot-printing/) is a liquid handling platform for performing automated solid-phase peptide synthesis. It is capable of automatic pipetting for sub-microliter dispensing and contact array printing applications in contact printing applications. This system spots Fmoc or t-Boc amino acid residues in dimethylformamide (DMF) on to solid surfaces, such as membranes, slides, filter paper or any other suitable array surface, in user-defined sequences. This workstation automates solid phase peptide synthesis in a simple and reproducible manner with extremely high yield and accuracy. The robotic arm is controlled by an external computer, allowing the user to micro-control the desired range of movement, sequence of individual peptides and standardize the spacing between spots.

### Features

- Highly customizable deck
- Nano-precision dispensing
- No impact on sensitive surfaces
- User friendly software interface
- Performs desired spotting procedure irregardless of the starting material and substrate used
- Most common spotting techniques can be efficiently automated
- Works on any array surface including slides and membranes

### Applications

- Solid-Phase peptide synthesis
- Protein/Peptide arrays
- Nucleic acid arrays
- Miniaturized assays
- Microarrays of solutions and reagents

 

 [DOWNLOAD APPLICATION NOTE](https://aurorabiomed.com/wp-content/uploads/2014/02/VERSA-Spotter-Workstation-Peptide-Synthesis.pdf)

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