Ion channels & transporters are important therapeutic targets in drug development pipelines and drug safety evaluation. These drug targets are critically important for a range of physiological conditions and disorders. Every year many drug candidates or under application drugs are withdrawn from the market due to cardiac-related adverse effects. Interestingly it has been shown that many adverse effects are due to the blockage in the human ether-a-go-go (hERG) ion channel, which delays repolarization of the cardiac action potential and can eventually result in a potentially fatal arrhythmia known as Torsades de Pointes (TdP). In particular, it has been found that compounds often exhibit cross-reactivity between closely related family members of their targets.
Aurora Biomed provides testing of your compound of interest against various ion channels and transporters using manual patch clamp (the gold standard method of electrophysiology) to the high throughput automated ion channel reader (ICR) technology. Our Scientists help you to determine the right assay format and platform for your specific requirements and also help you to run your experiments safely and fast all the way through your data interpretation. We help you to find solutions for your ion channel/transporter research that meet your needs.
Aurora Contract Research Services, using label-free technology and various animal models helps to make your drug discovery experimental design and data interpretation fast and easy. Contact us for a more in-depth discussion on how our provided assays can be customized to meet your specific goals.