Speaking Program and Schedule
24th July 2019
8:00 AM – 09:00 AM – Registration
09:00 AM – 09:10 AM – Opening Remarks: Aurora Biomed Inc.
Keynote Presentation
09:10 AM – 09:50 AM – Georg Terstappen
OxStem- “Label-free flux assay technologies in drug discovery and preclinical development”
09:50 AM – 10:30 AM – William Jia
Virogen Biotech Ltd.- “Oncolytic Virotherapy as a Precision Medicine”
10:30 AM – 11:00 AM – Coffee Break
Peptide Research in Drug Discovery – Precision Medicine
11:00 AM – 11:05 AM – Chair: Irina Vetter
University of Queensland
11:05 AM – 11:25 AM – Irina Vetter
University of Queensland– “The role of NaV1.6 in sensory neurons: insight from subtype-selective venom peptides”
11:25 AM – 11:45 AM – William Jia
Virogen Biotech Ltd.- “Peptide array platform for studying protein-protein interaction and potential development of novel drugs”
11:45 AM – 12:05 PM – Zhuyin Wang
Lanzhou University- “Construction and Screening of a Cyclic Peptide Library”
12:05 PM – 1:20 PM – Lunch
Parallel Sessions begin
-Start of Parallel Session 1-
Ion Channels in Epilepsy – Ion Channel
1:20 PM – 1:25 PM – Chair: JP Johnson
Xenon Pharmaceuticals
1:25 PM – 1:45 PM – JP Johnson
Xenon Pharmaceuticals- “NaV1.6 selective and NaV1.2/NaV1.6 dual Inhibitors Reduce Action Potential Firing in Mouse Cortical Pyramidal Neurons While Sparing Inhibitory Interneuron Firing”
1:45 PM – 2:05 PM – Merritt Maduke
Stanford University– “Development and validation of selective and potent small-molecule probes for the CLC-2 chloride channel”
2:05 PM – 2:25 PM – Terry Snutch
University of British Columbia– “P/Q-type Calcium Channel Dysfunction: an Underlying Mechanism in Sudden Unexpected Death in Epilepsy (SUDEP)?”
2:25 PM – 2:35 PM – Session Transition
Neurodegenerative Disease – Ion Channel & Precision Medicine
2:35 PM – 2:40 PM – Chair: Michelina Iacovino
LA Biomedical Research Institute
2:40 PM – 3:00 PM – Michelina Iacovino
LA Biomedical Research Institute- “Patient-derived organoid as a model to study Alzheimer’s Disease and drug development”
3:00 PM – 3:20 PM – Oleg Yerstein
University of California; Los Angeles- “The Role of Ion Channels in Dementia and Other Neurodegenerative Disorders”
3:20 PM – 3:40 PM – Aaron McMurtray
University of California; Los Angeles- “Precision Medicine in the Treatment of Neurodegenerative Diseases”
-End of Parallel Session 1-
-Start of Parallel Session 2-
Application & Advancement of Next Generation Sequencing – Precision Medicine
1:20 PM – 1:25 PM – Chair: David Smith
Mayo Clinic
1:25 PM – 1:45 PM – David Smith
Mayo Clinic– “The Massively Parallel Sequencing (MPS) Revolution”
1:45 PM – 2:05 PM – Laura Hilton
Simon Fraser University– “Oxford Nanopore long-read sequencing to refine somatic variant identification”
2:05 PM – 2:25 PM – Jason Underwood
Pacific Biosciences– “High-Resolution Views of the Human Genome and Transcriptome with PacBio SMRT Sequencing”
2:25 PM – 2:35 PM – Session Transition
Cancer Diagnosis & Treatment – Precision Medicine
2:35 PM – 2:40 PM – Chair: Chris Maxwell
BC Children’s Hospital
2:40 PM – 3:00 PM – Chris Maxwell
BC Children’s Hospital- “BRAvE at BC Children’s Hospital: a precision medicine research initiative for bone marrow-involved childhood cancers”
3:00 PM – 3:20 PM – Gregor Reid
BC Children’s Hospital- “Xenotransplantation of minimal residual disease reveals early enrichment of immunophenotypic subpopulations during leukemia therapy”
3:20 PM – 3:40 PM – Paul Li
Simon Fraser University– “Microfluidic Single-Cell Technology for Liquid Biopsy”
-End of Parallel Session 2-
3:40 PM – 4:10 PM – Coffee Break & Posters
Ion Channels & Immunity – Ion Channel
4:10 PM – 4:15 PM – Chair: Stefan Feske
New York University School of Medicine
4:15 PM – 4:35 PM – Stefan Feske
New York University School of Medicine- “Identification of novel ion channels regulating T cell-mediated immunity”
4:35 PM – 4:55 PM – Christine Beeton
Baylor College of Medicine- “Targeting KCa1.1 in fibroblast-like synoviocytes for the treatment of rheumatoid arthritis”
4:55 PM – 5:15 PM – Bimal Desai
University of Virginia- “TRPM7 at the Crossroads of Tissue Homeostasis and Inflammation”
5:15 PM – 5:35 PM – Cesare Sala
University of Florence- “Role of ERG1 channel in lymphocyte development and in leukemic clonal evolution”
25th July 2019
8:30 AM – 8:40 AM – Welcome & Opening Remarks + Chair of keynote speech
Keynote Presentation
8:40 AM – 9:20 AM – Samir Hanash
The University of Texas MD Anderson Cancer Center- “Liquid biopsy approaches from genomics and beyond”
9:20 AM – 10:00 AM – James Ellis
Nocion Therapeutics- “Novel Treatments for Pain, Cough and Itch by Selective Targeting of Sodium Channel Modulators into Nociceptors”
10:00 AM – 10:30 AM – Coffee Break & Posters
Ion Channels as Pain Targets I – Ion Channel
10:30 AM – 10:35 AM – Chair: Fernanda Laezza
University of Texas Medical Branch
10:35 AM – 10:55 AM – Fernanda Laezza
University of Texas Medical Branch- “Targeting the Nav1.6 channel with protein:protein interaction based allosteric modulators for pain management”
10:55 AM – 11:15 AM – Marzia Martina
National Research Council of Canada– “Functional antibodies against human Nav1.7 and their use in modulating pain”
11:15 AM – 11:35 AM – Chris Mathes
AnaBios Corporation, Inc.- “Using human DRG neurons in preclinical pain research”
11:35 AM – 11:55 AM – Marc Rogers
Metrion Biosciences- “Potent and selective state-dependent Cav2.2 calcium channel modulators with efficacy in preclinical pain models and human tissue”
11:55 AM – 12:15 PM – Jeffrey Herz
Algomedix- “Targeting TRPA1 for Development of Novel Analgesic Drugs”
12:15 PM – 1:30 PM – Lunch
Parallel Sessions begin
-Start of Parallel Session 1-
Ion Channels as Pain Targets II – Ion Channel
1:30 PM – 1:35 PM – Chair: Yan Xu
University of Pittsburgh
1:35 PM – 1:55 PM – Yan Xu
University of Pittsburgh- “Discovering Glycine Receptor Allosteric Modulators for Treatment of Chronic Pain”
1:55 PM – 2:15 PM – David Hackos
Genentech- “Structural basis of toxin binding to voltage-gated sodium channels and what it teaches us about voltage-gating mechanisms”
2:15 PM – 2:35 PM – Jie Zheng
University of California; Davis- “An in-silico approach towards solving ligand-host interactions in TRPV1 ion channels”
2:35 PM – 3:05 PM – Coffee Break & Posters
Cardiac Research, CiPA & the Impact on Drug Discovery – Ion Channel
3:05 PM – 3:10 PM – Chair: Najah Abi-Gerges
AnaBios Corporation, Inc.
3:10 PM – 3:30 PM – Elena Dragicevic
Nanion Technologies GmbH- “High Throughput Electrophysiology: Lessons from CiPA”
3:30 PM – 3:50 PM – Khaled Barakat
University of Alberta- “Computational Modeling of Cardiac Ion Channels”
3:50 PM – 4:10 PM – Najah Abi-Gerges
AnaBios Corporation, Inc.- “Adult Human Ex-Vivo Models for Preclinical Cardiac Safety Assessment of Drugs”
4:10 PM – 4:30 PM – Mohamed Chahine
Laval University and CERVO Brain Research Centre – “Gating pore currents underlie a new cardiac channelopathy”
-End of Parallel Session 1-
-Start of Parallel Session 2-
Stem Cells in Drug Discovery I – Ion Channel & Precision Medicine
1:30 PM – 1:35 PM – Chair: Marc Pourrier
IonsGate Preclinical Services Inc.
1:35 PM – 1:55 PM – Marc Pourrier
IonsGate Preclinical Services Inc.- “Overexpression of mutated ion channels in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) to model arrhythmogenic diseases.”
1:55 PM – 2:15 PM – Vincenzo Macri
STEMCELL Technologies- “Rescue of In Vitro Drug-Induced Long QT Syndrome Type 2 Using a HERG channel Activator in Human Pluripotent Stem Cell-Derived Ventricular-Like Cardiomyocytes”
2:15 PM – 2:35 PM – Heinrich Brinkmeier
University Medicine Greifswald– “Development of stem cell based cardiac pacemaker cells for in vitro drug testing”
2:35 PM – 3:05 PM – Coffee Break & Posters
Stem Cells in Drug Discovery II – Ion Channel & Precision Medicine
3:05 PM – 3:10 PM – Chair: Jonathan Davila
NeuCyte
3:10 PM – 3:30 PM – Jonathan Davila
NeuCyte- “Overcoming Challenges in CNS Drug Discovery through Developing Translatable iPSC-derived Cell-Based Assays”
3:30 PM – 3:50 PM – Daniel Sauter
Sophion Bioscience– “Towards more physiological assays: iPSC-derived neurons tested on the 384 channel automated patch clamp platform Qube”
3:50 PM – 4:10 PM – Zhiyuan Li
Guanzhou Institutes of Biomedicine and Health– “Generation of an induced pluripotent stem cell (iPSC) line from a 16-year old male with autism spectrum disorder (ASD)”
4:10 PM – 4:30 PM – Georg Terstappen
OxStem– “Small molecule drug discovery targeting innate regeneration and repair”
-End of Parallel Session 2-
6:00 PM – 9:00 PM-
Social Event- Boat Cruise
26th July 2019
8:30 AM – 8:35 AM – Chair of keynote speech
Keynote Presentation
8:35 AM – 9:15 AM – David Smith
Mayo Clinic- “Whole Genome Sequencing to Study the Role of HPV Integration In Oropharyngeal Squamous Cell Carcinoma”
9:15 AM – 9:55 AM – Dong Liang
Aurora Biomed- “Flux Assays for Ion Channels and Transporters (Novel Area for Cancer Drug Discovery)”
9:55 AM – 10:25 AM – Coffee Break & Posters
Ion Channels in Drug Discovery – Ion Channel
10:25 AM – 10:30 AM – Chair: Isabelle Deschenes
Case Western Reserve University
10:30 AM – 10:50 AM – Isabelle Deschenes
Case Western Reserve University- “Voltage-Gated Sodium Channels Assemble and Gate as Dimers”
10:50 AM – 11:10 AM – Yuji Imaizumi
Nagoya City University– “Development of a novel cell-based assay system for high throughput screening of compounds acting on background two-pore domain K+ channels”
11:10 AM – 11:30 AM – Alberto Montalbano
University of Florence- “A signalling pathway centred on hERG1 potassium channel identifies metastatic colorectal cancer patients with a positive response to Bevacizumab.”
11:30 AM – 11:50 AM – Wayne Giles
University of Alberta- “Electrophysiological Properties of Human Chondrocytes Can Yield Insights into Design of Drug Targets and Discovery Platforms”
11:50 AM – 1:05 PM – Lunch
Structural and functional aspects of ion channels and ion transporters – Ion Channel
1:05 PM – 1:10 PM – Chair: Tzyh-Chang Hwang
University of Missouri
1:10 PM – 1:30 PM – Tzyh-Chang Hwang
University of Missouri- “Hunting the Molecular Target Sites for CFTR Potentiators”
1:30 PM – 1:50 PM – Paul Schnetkamp
University of Calgary- “Structure-function, physiology and pharmacology of K-dependent Na-Ca exchangers of the SLC24 gene family”
1:50 PM – 2:10 PM – George Okeyo
Nanion Technologies- “SSM-based Functional Recordings of Cardiac Transporters and Pumps”
2:10 PM – 2:15 PM – Session Transition
Key Methodologies in Precision Medicine & Ion Channels for Drug Discovery
2:15 PM – 2:20 PM – Chair: Owen McManus
Q-State
2:20 PM – 2:40 PM – Filip Van Petegem
University of British Columbia– “High-resolution insights in ion channels involved in muscle excitation-contraction coupling”
2:40 PM – 3:00 PM – Amanda Duran
Cyrus Biotechnology– “Functional and Mutational Analysis with Rosetta and Cyrus Bench: KCNQ1 case study”
3:00 PM – 3:20 PM – Ali Yehia
Fluxion Biosciences- “Importance of fluidic control and precision in serial activation of ionic channels”
3:20 PM – 3:40 PM – Owen McManus
Q-State– “Precision medicine targeting genetically defined CNS disorders using human iPS cell models”
3:40 PM – 3:50 PM – Closing Remarks: Dong Liang
Aurora Biomed Inc.
-End of PMICR-