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A Simple Guide to Label-free Drug Screening Technology

As a scientist doing research in ion channel and transporter, you know how difficult it can be to perform drug screening. Non-radioactive Rubidium Efflux assay technology is one of the top screening methods to help you with your research.

This label-free micro-sampling technology in laboratories, including sample prep, readout, data gathering, analysis, and reporting, is an important stage. Using Ion Channel Reader (ICR) technology is crucial for increasing the effectiveness of research labs and hastening the drug discovery process. ICR systems in the lab can expedite compound screening processes, improve the consistency and accuracy of results, lower personnel expenses, and permit more sophisticated experiments that would otherwise be impractical. Furthermore, ICR can also help increase biohazardous safety levels in the processing of samples.

How Can Ion Channel Reader Help Streamline Your Research Process?

Ion Channel Reader (ICR) technology has changed how drug discovery research is carried out in laboratories. It has streamlined the screening process by enabling researchers to automate time-consuming and laborious processes safely.

Automating processes like ion flux assay with AAS as readout is possible with ICR technology and present a direct measure of channel activity.

By automating ion channel and transporter screening, researchers can increase the throughput level of their work while assuring consistency and precision in their research. Additionally, ICR aids in reducing errors that could arise during manual procedures, improving study outcomes.

Benefits of Using ICR for Different Types of Experiments

The application of ICR technology in labs has been increasing and allows researchers to streamline their projects more effectively and with more safety features. It allows to save time and cost while producing reliable research results.

ICR instrument enables scientists to quickly and precisely run a considerable number of samples (mid-high throughput) and keep their outcomes accurate and reproducible.

Increasing the throughput level per hour is possible using an ICR workstation. The Ion Channel Readers (ICR) combine the versatility, precision, and sensitivity of atomic absorption spectroscopy (AAS) with the micro-sampling process and liquid handling technologies, creating a high-throughput screening solution for ion channel researchers that fills gaps which automated patch-clamp cannot. It reduces human error and decrease sample waste.

The application of ICR will scale up your experiments without scaling up your budget or taking up valuable lab space. No matter the size of the laboratory, investing in an ion channel reader has several advantages. The standardization of test performance is the first benefit. Compared to manual/automated patch clamps, other ion channel reader instruments, and high-throughput, multi-electrode array platforms, there is less chance of errors with less human involvement and cross-contamination.

The cost of Ion Channel Reader!

Ion channel readers can be costly instruments to acquire and maintain, and the cost-effectiveness of an ion channel reader depends on many factors, such as the specific instrument, the intended use, and the available budget. In general, ion channel readers are expensive instruments due to the complexity of their design and the high level of precision required for their operation. They can also require expensive consumables, such as pipette tips and assay plates, and may need periodic maintenance and calibration, which can add to the cost.

However, if an ion channel reader is essential for a particular research project or drug discovery program, it can be a cost-effective investment in the long term. By accurately measuring the activity of ion channels, an ion channel reader can help identify potential drug candidates more efficiently and effectively than other methods, ultimately saving time and money in the drug development process.

Aurora’s ion channel readers are designed for mid to high-throughput screening, which can increase the efficiency of drug discovery and make the instrument more cost-effective. High-throughput screening allows researchers to test large numbers of compounds simultaneously, reducing the time and cost required for screening.

How to Choose the Right Ion Channel Reader for Your Laboratory Needs?

Choosing the right ion channel reader for your laboratory can be a complex process, as there are many factors to consider, such as the type of ion channel you are interested in, the throughput and sensitivity required for your experiments, and your budget. Here are some key factors to consider when choosing an ion channel reader:

  • Ion channel type: Different ion channel readers are designed to measure different types of ion channels, such as voltage-gated, ligand-gated, or mechanosensitive channels. It is important to choose an instrument that is compatible with the specific ion channel of interest.
  • Throughput: The throughput of an ion channel reader refers to the number of wells or cells that can be measured simultaneously. High-throughput screening instruments can measure hundreds or thousands of wells in a short period of time, while lower-throughput instruments may be better suited for more specialized or detailed experiments.
  • Sensitivity: The sensitivity of an ion channel reader refers to the level of detection of ion channel activity. Some instruments are more sensitive than others and can detect smaller changes in ion channel activity, which may be important for certain applications.
  • Automation: Automated instruments can perform tasks such as pipetting, mixing, and plate handling, which can reduce human error and increase the reproducibility of experiments. Fully automated systems are generally more expensive than partially automated or manual systems.
  • Cost: Ion channel readers can vary in price depending on their features, sensitivity, and throughput. It is important to consider the cost of the instrument and any associated consumables, maintenance, and support when choosing an ion channel reader.
  • Compatibility with other instrumentation: If you plan to use the ion channel reader with other laboratory equipment, such as liquid handling systems or robotics, it is important to ensure the instrument is compatible and can integrate with these other systems.
  • Reputation and support: It is important to consider the reputation and support of the manufacturer and distributor of the ion channel reader. Look for a company with a good track record in ion channel research that provides reliable technical support and service. The benchtop space available


Choosing the right ion channel reader for your laboratory requires careful consideration of your experimental needs and budget, as well as instrument features and capabilities of the instrument. It is important to conduct thorough research, compare options, and seek advice from experts in the field before making a purchase. An appropriately chosen ion channel reader can significantly enhance drug discovery research and prove to be a valuable asset for your laboratory in the long run.


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