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Ion Channel Technology – News and Updates

HIGH THROUGHPUT SCREENING ASSAY FOR ACID-SENSING ION CHANNELS

Acid-sensing ion channels (ASICs) are members of the amiloridesensitive epithelial Na+-channel/degenerin superfamily (ENaC/DEG). These ligand-gated ion channels areactivated by protons, which are released during tissue acidosis (increase in extracellular acidity). Tissue acidosis, which is evidence...
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Elemental Analysis Application

Screening of Natural Compounds for Pharmaceuticals

In the journey to discover novel and efficient medications for diverse diseases, scientists and researchers have redirected their focus toward the expansive repository of natural compounds present in plants, animals, and microorganisms. The process of screening these natural compounds for their pote...
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Blog-Post-How-to-study-Potassium-ion-Channels

A Simple Guide to Label-free Drug Screening Technology

As a scientist doing research in ion channel and transporter, you know how difficult it can be to perform drug screening. Non-radioactive Rubidium Efflux assay technology is one of the top screening methods to help you with your research. This label-free micro-sampling technology in laboratories,...
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Blog-Post-How-to-study-Potassium-ion-Channels

K+ Potassium Channels: How to study them?

What roles do K+ potassium channels play? Potassium (K+ channels) are almost every organism's most widely distributed ion channel. Potassium channels allow the flow of potassium ions across the membrane but block the flow of other ions, specifically sodium (Na+) ions. These channels are made of two...
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A light spectrum with ions from a channel protein that produce an absorbance band. This light that has gone through elements of an ion channel can then be identified. Text on the image says Label-free technology. The background is outerspace. Feature image from the blog post Ion channel label-free technology: What is it?

Ion channel label-free technology: What is it?

In 2000, Aurora Biomed became the first company that developed a non-radioactive, label-free technology for high throughput screening of ion channel and transporter targets. Aurora’s ion channel reader (ICR) technology has been rapidly incorporated into many pharmaceutical drug discovery pipelines...
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The Nobel prize in Physiology or medicine 2021. How Aurora's Ion Channel Reader helps with TRPV1 research. The ICR 12000 has been used in Drug Discovery. Image made by Niklas Elmehed

Aurora’s Ion Channel Reader helps TRPV1 research

On October 4, 2021, the Nobel Prize in Physiology and Medicine was awarded to David Julius and Ardem Patapoutian. David Julius discovered the temperature receptor, TRPV1 ion channel, and Ardem Patapoutian discovered the pressure receptor, PIEZO ion channel....
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Cure-ious Invertebrates

Many of our best drugs are derived from natural sources. Most people will first think of the curative properties of plants such as willows (acetylsalicylic acid, Aspirin) and Pacific Yew (paclitaxel, a cancer-fighting agent).
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Ion Channel Retreat 2014: Ligand-gated channels

This year's event is shaping up to be especially interesting with topics such as ion channels in disease and pain, ion channel screening technologies for assessment of cardiac safety and toxicology, structure and function of ion channels, and new this year a session focusing on transporter molecules and their roles with ion channels.
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