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Automated Liquid-Liquid Extraction (LLE) Systems

The VERSA automated Liquid Liquid Extraction (LLE) system, also known as an automated solvent extractor, offers the most flexibility and throughput among all other liquid handlers, by utilizing our innovative modules:

  • Conductive Liquid Level Sensing – detects phase boundary and ensures precision, reproducibility, and minimal dead volume
  • ReagentDrop Bulk Dispensing Module – dispenses solvents (including organic solvents) and reagents without using tips, prevents dripping of volatile solvents
  • On-deck Tube/Plate Shaker – for mixing and online reconstitution
  • Heater Assisted Nitrogen Dryer – enables a complete walk-away solution for liquid-liquid extractions
  • Versatile Labware – adaptors available for virtually any shape and size (microcentrifuge tubes, test tubes, vials, etc.)

The VERSA Automated Solvent Extraction systems are highly scalable for different throughput and budget requirements. These instruments can automate a number of applications, including extractions of drugs-of-abuse and other metabolites of interest from bodily fluids, as well as biomolecules of interest from biological matrices (such as lipids and proteins). Please contact us for additional information and applications.

Independently Validated

Dr. Adrian Franke from Cancer Research Center of Hawaii is using VERSA Automated Liquid Liquid Extraction workstation to study Phytoestrogenic Isoflavonoids in epidemiologic and clinical research.

Download the validation paper to see how the VERSA automated Liquid-Liquid Extraction system is making a difference in cancer research.

Modules Tailored to Automate Your Automated Liquid Liquid Extraction Workflow

ReagentDrop
Nitrogen Dryer for Automated Solid Phase Extraction System (SPE Automation)

Dual Module for Efficiency

single channel pipetting head and ReagentDrop in a single compact system

ReagentDrop

draws reagents from their reservoirs and eliminates tip usage – prevents dripping of volatile solvents

Nitrogen Dryer

enables on-deck sample drying

Reagent Block Cooler

cools reagents to reduce volatilization

Heater Shaker with PCR plate
Current Gripper
VERSA 1100 automated liquid handling system

Shaker-Heater

efficiently mixes organic solvents and aqueous samples

Gripper

moves Nitrogen Dryer for on-deck sample drying

Vial Holders

houses 24, 32, 35, 48 test-tubes/vials

(compatible with HPLC vials)

Exhaust Hood

protects lab personnel from harmful and volatile organic solutions

  • Capable of processing Automated Solid Phase Extraction on the same workstation
  • Low dead volume maximizes sample recovery
  • Conductive liquid level sensing to detect phase boundary
  • Compatibility with organic and aqueous reagents
  • Exhaust provision for volatile reagents
  • HEPA/UV/LED Enclosure – keeps samples contamination-free
  • Unparalleled Customer Service – our engineering team is readily available to troubleshoot your protocols

Specifications

VERSA 110 VERSA 1100 Automated Liquid Handling Station for Solid Phase Extraction and Liquid Liquid Extraction

VERSA 1100

Deck Capacity 8 15
Pipetting Head
(Single Channel Function, Disposable Tip)
Single chnnel with dual syringe pump 4 or 8 channel
ReagentDrop up to 4 up to 8
Supported Labware Formats 24, 48 test-tubes/vials and 96 deep well plates 24 test-tubes/vials and 96 deep well plates
Gripper / Plate Transporter Plate Transporter Gripper
Reagent Block / Flat Plate Coolers Either Either
Nitrogen Dryer N/A 24 or 96 channels
Shaker-Heater (2400rpm, RT to 90°C) Included Included
Liquid Level Sensing Optional Optional
HEPA/UV/LED Enclosure Optional Optional
Width x Depth x Height (cm) 59 x 66 x 90 99 x 75 x 90
Weight (kg) 40 162

Applications

  • Sports Medicine
  • Vitamin D from Blood/Serum Samples
  • Drugs of Abuse in Forensic Analysis
  • Compounds for Drug Discovery
  • Iso-Flavonoides from Urine Samples
  • Aflatoxins from Seafood Products
  • Lipid Extraction
  • Growth Promoters in Blood
  • Semi-Volatile or Non-Volatile Analytes

Frequently Asked Questions

VERSA Automated Liquid-Liquid Extraction (LLE) workstations offer the most flexibility and throughput among all liquid handlers, due to the inclusion of our innovative modules. VERSA workstations are very flexible and open, allowing compatibility with almost all kits, reagents, and labwares available in the market.

To minimize solvent evaporation, the included ReagentDrop channels dispense bulk reagents directly from sealed compartments (pressurized-bottle) located off the deck. These sealed compartments reduce reagent evaporation and exposure resulting from highly volatile reagents such as methanol. The VERSA Automated Liquid-Liquid Extraction workstation is armed with an exhaust to deal with volatile reagents. Additionally, as the ReagentDrop dispenses organic solutions without using tips, dispensing can be done quickly for large and small volumes, and tip usage is decreased.

Yes, the nitrogen dryer block can be used for solvent evaporation and sample concentration, and it can be transferred into a drying position above the test tubes/vials by the plate gripper. The combination of shaker-heater, nitrogen dryer, and gripper enables complete walk-away solution for any LLE protocols.

VERSA is equipped with a powerful shaker for vortex mixing of organic solvents and aqueous samples, and the timing and speed (RPM) of the shaking process can be optimized for your application, as well as changed on demand within the included software.

Yes, VERSA LLE workstation features Conductive Liquid Level Sensing for detecting the phase boundary between organic and aqueous solvents, ensuring precision and reproducibility in your LLE procedures. Alternatively, you have the option to define aspirate heights (Z position) to remove one liquid/phase from the other.

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